(2-hydroxypropyl)-alpha-cyclodextrin Solution 10% (w/v) Catalog # K1010005B Lot # Batch Dependent Expiration Batch Dependent Amount 25 mL Concentration 10% (w/v) Supplied as Solution Applications Solubility enhancement, molecular assemblies, organic synthesis Storage 2–8°C Keywords HPαCD, α‐HPCD, 2‐hydroxypropyl‐α‐CD, HP-α-CD, 2OHpαCD Grade Biotechnology grade; ultrapure water, 0.22 µm filtered This 10% (w/v) solution of (2-hydroxypropyl)-alpha-cyclodextrin (HPαCD) is a versatile reagent used in solubility enhancement, host–guest chemistry, and formulation development. HPαCD is a modified cyclic oligosaccharide that improves the aqueous solubility of poorly soluble compounds by forming inclusion complexes. Its alpha-cyclodextrin backbone offers a smaller cavity size, making it ideal for encapsulating low-molecular-weight hydrophobic guests. Supplied as a clear, ready-to-use solution in ultrapure water, this reagent is filtered through 0.22 µm membranes and packaged in 25 mL aliquots. It is widely used in pharmaceutical formulation, supramolecular chemistry, and analytical method development. Researchers working in drug delivery, molecular encapsulation, and solubilization of bioactive compounds will find this reagent highly effective and reproducible. Key benefits: 10% (w/v) HPαCD solution for solubility enhancement Supports host–guest chemistry and molecular encapsulation Filtered through 0.22 µm for analytical compatibility Ideal for pharmaceutical, biochemical, and synthetic workflows Supplied in ultrapure water; biotechnology grade Indication for Use:This product is for Research Use Only (RUO). This product is not for administration to humans or animals. This product is not for human or veterinary diagnostic or therapeutic use. References:1: Hoque S, Kondo Y, Sakata N, Yamada Y, Fukaura M, Higashi T, Motoyama K, ArimaH, Higaki K, Hayashi A, Komiya T, Ishitsuka Y, Irie T. Differential Effects of2-Hydroxypropyl-Cyclodextrins on Lipid Accumulation in Npc1-Null Cells.Int J Mol Sci. 2020 Jan 30;21(3):898. 2: Tomono K, Goto H, Suzuki T, Ueda H, Nagai T, Watanabe J. Interaction ofiodine with 2-hydroxypropyl-alpha-cyclodextrin and its bactericidal activity.Drug Dev Ind Pharm. 2002 Nov;28(10):1303-9. 3: Motoyama K, Hashimoto Y, Hirayama F, Uekama K, Arima H. Inhibitory effects of2,6-di-O-methyl-alpha-cyclodextrin on poly I:C signaling in macrophages. Eur JPharm Sci. 2009 Feb 15;36(2-3):285-91. 4: Holm R, Schönbeck C, Askjær S, Jensen H, Westh P, Østergaard J. Complexationof tauro- and glyco-conjugated bile salts with α-cyclodextrin and hydroxypropyl-α-cyclodextrin studied by affinity capillary electrophoresis and molecularmodelling. J Sep Sci. 2011 Nov;34(22):3221-30. 5: Zarzycki PK, Ohta H, Saito Y, Jinno K. Interaction of native alpha-cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin and their hydroxypropylderivatives with selected organic low molecular mass compounds at elevated andsubambient temperature under RP-HPLC conditions. Anal Bioanal Chem. 2008Aug;391(8):2793-801. 6: Liu B, Li W, Nguyen TA, Zhao J. Empirical, thermodynamic and quantum-chemicalinvestigations of inclusion complexation between flavanones and(2-hydroxypropyl)-cyclodextrins. Food Chem. 2012 Sep 15;134(2):926-32. 7: Terekhova IV, Scriba GK. Study on complex formation of biologically activepyridine derivatives with cyclodextrins by capillary electrophoresis. J PharmBiomed Anal. 2007 Nov 30;45(4):688-93. 8: Rizzi V, Matera S, Semeraro P, Fini P, Cosma P. Interactions between4-thiothymidine and water-soluble cyclodextrins: Evidence for supramolecularstructures in aqueous solutions. Beilstein J Org Chem. 2016 Mar 21;12:549-63. 9: Warne LN, Beths T, Whittem T, Carter JE, Bauquier SH. A review of thepharmacology and clinical application of alfaxalone in cats. Vet J. 2015Feb;203(2):141-8.10: Kimura K, Hirayama F, Arima H, Uekama K. Solid-state 13C nuclear magneticresonance spectroscopic study on amorphous solid complexes of tolbutamide with2-hydroxypropyl-alpha- and -beta-cyclodextrins. Pharm Res. 1999Nov;16(11):1729-34.
