5-Hydroxytryptophan (5-HTP) – Thorne 5-HTP is a naturally occurring intermediate in the body’s conversion of the essential amino acid L-tryptophan into serotonin, a neurotransmitter critical for regulating mood, sleep, and appetite.* Supplementing with 5-HTP bypasses the rate-limiting step of tryptophan hydroxylase, which can be impaired by stress, age, insulin resistance, or deficiencies in vitamin C, folate, or iron. Key Benefits: Supports balanced serotonin levels in the central nervous system Promotes restful sleep and improved mood* Reduces sugar and carbohydrate cravings* May alleviate fatigue-related discomfort* Mechanism: 5-HTP is well absorbed orally (≈70% enters the bloodstream) and crosses the blood-brain barrier efficiently. Thorne’s formula includes pyridoxal 5'-phosphate (active vitamin B6), the cofactor necessary for converting 5-HTP into serotonin. Suggested Use: Take 1–2 capsules, up to three times daily, or as directed by a healthcare professional. Can be taken with meals without reducing effectiveness. Safety and Warnings: Allergy: Avoid if hypersensitive to any ingredients. Pregnancy/Nursing: Do not use if pregnant or nursing. Interactions: Use caution if taking SSRIs, MAO inhibitors, or other antidepressants due to risk of serotonin excess. Source: Extracted from the seeds of Griffonia simplicifolia; each lot is tested for contaminants, including being Peak X free. This supplement is primarily aimed at supporting mood, sleep, and serotonin-mediated appetite regulation.*
