Nicotinamide, also known as Vitamin B3, is a non-competitive inhibitor of sirtuins, and its inhibitory effect affects a variety of important regulatory mechanisms in vitro and in vivo. Nicotinamide strongly inhibits yeast SIR2-mediated transcriptional silencing, increases rDNA recombination, and shortens replication lifespan. The yeast enzyme PNC1 converts nicotinamide to nicotinic acid, which activates Sir2 and prevents nicotinamide from telomere inhibition and rDNA silencing. Nicotinamide inhibits the deacetylation of p53 and inhibits the deacetylation of histones H3 and H4. Nicotinamide induces apoptosis in a variety of tumor cells, accompanied by caspase cascade activation. Nicotinamide has been used in preclinical trials for the treatment of cancer and type 1 diabetes. Features Purity≥99% Standardized production, using factory mass production mode Specifications Cat.No. 51402ES03/51402ES08 Size 1 g/5 g Synonym Niacinamide, Nicotinic acid amide, Vitamin B3, pyridine-3-carboxamide Target PARP1 CAS No. 98-92-0 Molecular formula C6H6N2O Molecular weight 122.12 Appearance solid powder Purity ≥99% Solubility Soluble in DMSO, ethanol and water Structure Components Components No. Name 51402ES03 51402ES08 51402 Nicotinamide 1 g 5 g Shipping and Storage The Nicotinamide products should be stored at -15～-25℃ for 2 years. Avoid repeated freeze-thaw cycles. Documents: Safety Data Sheet 51402_MSDS_HB20250210 _EN.pdf Manuals 51402_Manual_HB20250210 _EN.pdf
