Y-27632 dihydrochloride (also known as Y27632 dihydrochloride, Y 27632 dihydrochloride, Y27632 2HCl) is a potent, selective, ATP-competitive ROCK inhibitor that acts on ROCK1 (p160ROCK) (Ki=140 nM) and ROCK-II (IC50=800 nM) and inhibits PRK2 activity. Y-27632 acts on human embryonic stem cells (hES) to significantly reduce apoptosis induced by cell isolation and improve cloning efficiency. Y-27632 can also promote the proliferation of human corneal epithelial cells cultured in vitro. Features Purity≥98% Standardized production, using factory mass production mode Specifications Cat.No. 52604ES08/52604ES10/52604ES25/52604ES50/52604ES60 Size 5 mg/10 mg/25 mg/50 mg/100 mg Synonym Y-27632 2HCl Target ROCK-I; ROCK-II CAS No. 129830-38-2 Molecular formula C14H21N3O • 2HCl Molecular weight 320.26 Appearance solid powder Purity ≥98% Solubility Soluble in H2O; soluble in DMSO Structure Components Components No. Name 52604ES08 52604ES10 52604ES25 52604ES50 52604ES60 52604 Y-27632 dihydrochloride 5 mg 10 mg 25 mg 50 mg 100 mg Shipping and Storage The Y-27632 dihydrochloride products should be stored at -15～-25℃ for 2 years. Avoid repeated freeze-thaw cycles. Documents: Safety Data Sheet 52604_MSDS_HB20250210 _EN.pdf Manuals 52604_Manual_HB20250210 _EN.pdf
