A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 (IC50: 12 nM)/ALK4 ((IC50: 45 nM)/ALK7 (IC50: 7.5 nM) kinase, A 83-01 has a strong inhibitory effect on ALK5 and can inhibit phosphorylation of Smad2/3 and TGF-β-induced growth. A 83-01 has little or no effect on bone morphogenetic protein type I receptors, p38 mitogen-activated protein kinases, or extracellular regulatory kinases. At the same time, A 83-01 inhibits TGF-β-induced epithelial-mesenchymal metastases, suggesting that A 83-01 may help inhibit the progression of advanced cancer. Features Purity≥98% Standardized production, using factory mass production mode Specifications Cat.No. 53002ES03/53002ES08/53002ES10 Size 1 mg/5 mg/10 mg Synonym A83-01; A 83 01; A83-01 Target ALK7; ALK5; ALK4 CAS No. 909910-43-6 Molecular formula C25H19N5S Molecular weight 421.52 Appearance solid powder Purity ≥98% Solubility soluble in DMSO Structure Components Components No. Name 53002ES03 53002ES08 53002ES10 53002 A 83-01 1 mg 5 mg 10 mg Shipping and Storage The A 83-01 products should be stored at -15～-25℃ for 2 years. Avoid repeated freeze-thaw cycles. The product is unstable in the solution state, so it is recommended to prepare it for immediate use. Documents: Safety Data Sheet 53002_MSDS_HB20250210 _EN.pdf Manuals 53002_Manual_HB20250210 _EN.pdf
