CHIR-99021 is an amino pyrimidine derivative and a potent inhibitor of GSK-3α (IC50: 10 nM) and GSK-3β (IC50: 6.7 nM). CHIR-99021 has over 500 times selectivity for GSK-3 compared to the closest homologs CDC2, ERK2, and other protein kinases. CHIR-99021 activates the Wnt/β-catenin signaling pathway and induces cardiomyocyte differentiation of embryonic stem cells. Features Purity≥98% Standardized production, using factory mass production mode Specifications Cat.No. 53003ES05/53003ES08/53003ES10 Size 2 mg/5 mg/10 mg Synonym CT99021；CHIR99021 Target GSK-3α；GSK-3β CAS No. 252917-06-9 Molecular formula C22H18Cl2N8 Molecular weight 465.34 Appearance solid powder Purity ≥98% Solubility soluble in DMSO Structure Components Components No. Name 53003ES05 53003ES08 53003ES10 53003 CHIR-99021 2 mg 5 mg 10 mg Shipping and Storage The CHIR-99021 products should be stored at -15～-25℃ for 2 years. Avoid repeated freeze-thaw cycles. Documents: Safety Data Sheet 53003_MSDS_HB20250210 _EN.pdf Manuals 53003_Manual_HB20250210 _EN.pdf
