Doxycycline Hyclate, is a syntheic oxytetracycline broad-spectrum antibiotic, primarily targeting bacteria responsible for respiratory infections, including Mycoplasma pneumoniae and Haemophilus influenza. Additionally, it can be used to treat variety of infections such as Lyme disease, Rickettsia, and some spirochetes, and has antigenic and insect repellent functions. Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. Doxycycline Hyclate is also an inhibitor of matrix metalloproteinases (MMP), including MMP-8 (neutrophil collagenase; IC50: 30 μM) and MMP-1 (interstitial collagenase; IC50: 300 µM). Doxycycline Hyclate has been observed to significantly decrease the levels and activity of metalloproteinase-9 (MMP-9) in corneal erosion studies. Doxycycline Hyclate blocks collagen activity and increases smooth muscle cell adhesion, and changes the reorganization of fibrillar collagen matrices and cell migration in smooth muscle studies. Doxycycline hydrochloride is also commonly used in tet-on (rtTA dependent) and tet-off (tTA dependent) systems to regulate gene expression, both in vivo and in vitro. For other antibiotics, please refer to the related topic of Antibiotic User Manual. Features Potency (Anhydrous)：800-920 μg/mg Standardized production, using factory mass production mode Applications Cell culture Used to treat variety of infections Specifications CAS NO. 24390-14-5 Molecular Fomular C22H24N2O8·HCl·0.5H2O·0.5C2H6O Molecular Weight 512.94 g/mol Appearance Light yellow powder Potency (Anhydrous) 800-920 μg/mg Solubility Soluble in water Structure Components Components No. Name 60204ES03 60204ES08 60204ES25 60204 Doxycycline Hyclate 1 g 5 g 25 g Shipping and Storage The Doxycycline Hyclate products be stored at 2～8℃ for 2 years. The aqueous solution can only be stored stably at 2～8℃ for 5 days, and can be stored at for a longer term at -25～-15℃. Documents: Safety Data Sheet 60204_MSDS_HB250210_EN.pdf Manuals 60204_Manual_HB250210_EN.pdf
