Interleukin 7 (IL-7) is a cytokine involved in the regulation of immune cell development and survival, including T and B lymphocytes. It is produced by stromal cells, such as fibroblasts and bone marrow stromal cells. Dysregulation of IL-7 signaling has been implicated in autoimmune diseases and cancer. Product information Synonyms Interleukin 7, IL7, IL-7, IL-7interleukin-7, interleukin 7, Lymphopoietin-1, PBSF Species Human Expressed Sequence Asp 26 – His 177 Uniprot No. P13232 Tag No Tag Expression System E.coli Molecular Weight Approximately 17.4 kDa, a single non-glycosylated polypeptide chain containing 152 amino acids. Purity > 95% as determined by SDS-PAGE and HPLC. Endotoxin < 1.0 EU per μg by the LAL method. Formulation Lyophilized from a 0.2 μm filtered concentrated solution in 20 mM PB, 150 mM NaCl, pH 7.4. Appearance Lyophilized Powder Biological Activity Fully biologically active when compared to standard. rHuIL-7 stimulates proliferation of PHA-activated human peripheral blood mononuclear cell (PBMC). The specific activity of Recombinant Human IL-7 is > 1.0 × 10^8 Units/mg, which is calibrated against human IL-7 standard. Reconstitution Centrifuge tubes before opening. Dissolve lyophilized protein with sterile PBS to ensure the concentration is greater than 100 μg/mL. Storage The product should be stored at -25~-15℃ for 1 year from date of receipt. 2-7 days, 2 ~8 °C under sterile conditions after reconstitution. 3 months, -25~-15℃ under sterile conditions after reconstitution. Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles. Notes 1.Please operate with lab coats and disposable gloves,for your safety. 2.This product is for research use only. Documents: Manuals: 90188_Manual_HB20260708
