Interleukin-17A (IL-17A), also known as CTLA-8, is a 15-20 kDa glycosylated cytokine that plays an important role in anti-microbial and chronic inflammation. Product Properties Synonyms Interleukin 17；CTLA8; CTLA-8;Cytotoxic T-lymphocyte-associated antigen 8; IL17; IL-17; IL17A; IL-17A; Uniprot No. Q62386 Source Mouse IL-17A Protein is expressed from HEK293 without tag. It contains Ala26-Ala158. Molecular Weight The protein has a predicted 15.0 kDa Purity > 95% as determined by SDS-PAGE. Biological Activity Measured by its ability to induce IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells. The EC50 for this effect is 0.12-1.25 ng/mL. Endotoxin < 0.01 EU per 1 μg of the protein by the LAL method. Formulation Dissolved in sterile PBS buffer. This solution can be diluted into other aqueous buffers. Centrifuge the vial prior to opening. Concentration 0.2 mg/mL Shipping and Storage The product should be stored at -85~-65℃ for 1 year from date of receipt. Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles. Figure Figure 1.Measured by its ability to induce IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells. The EC50 for this effect is 0.12-1.25 ng/mL. Figure 2.4 ug/lane protein was resolved with SDS-PAGE under non-reducing (NR) and reducing (R) conditions and visualized by Coomassie Blue staining. Cautions 1. For your safety and health, please wear lab coat and disposable gloves. 2. This product is for scientific research purposes only.
