Interleukin-23 (IL-23) is a pro-inflammatory heterodimeric protein consisting of two subunits: a unique p19 subunit and a p40 subunit shared with IL-12.IL-23 is secreted by activated dendritic cells and macrophages and signals through the receptor for IL-23R in complex with IL-12Rβ 1. IL-23 has been shown to enhance the proliferation of memory T cells. It also stimulates IFN-γ production in NK cells, induces IL-17 production, and drives Th17-mediated responses. This Recombinant Human IL-23 is supplied in liquid form, highly active, highly pure, low endotoxin, and label free. Specification Synonyms Interleukin-23；IL23 Source HEK293 Source Human IL-23 p40（Ile23-Ser328）&Human IL-23 p19 (Arg20-Pro189) Accession p40（P29460）& p19（AAG37232） Molecular Weight Predicted Moleucular weight: 36.5 kDa (p40) & 18.5 kDa (p19) Endotoxin < 0.01 EU/μg by the LAL method. Purity > 95%，determined by SDS-PAGE. Biological Activity Measured by its ability to induce IL-17 secretion by mouse splenocytes.The EC50 for this effect is 0.25 pg/mL. Formulation Dissolved in sterile PBS buffer. Tag No Physical Appearance Liquid concentration 0.2 mg/mL Storage -85~-65℃ storage, valid for 1 year after receipt. Avoid repeated freezing and thawing, centrifuge before opening the vial. It is recommended to aliquot for one experimental use, after aliquoting, freeze at -80℃. Cautions 1. Please operate with lab coats and disposable gloves,for your safety. 2. This product is for research use only.
