Many autoimmune skin diseases, such as herpetic pemphigoid (BP), psoriasis, and certain types of chronic urticaria, are associated with intense itching. Although histamine and neuropeptides were previously thought to play a role in the itching that accompanies these diseases, recent evidence suggests that the itch-causing cytokine interleukin (IL)-31 is a major driver of the itch response.IL-31 was initially shown to be produced by activated helper T-cells, particularly Th2 cells, mast cells, macrophages, and dendritic cells.Product Properties. Synonyms Interleukin-31; IL-31;IL31 Species Canine Source HEK293 Sequence Ala27-Gln159 Accession BAH97742.1 Tag N-His Molecular Weight The protein has a predicted MW of 16.63 kDa. Due to glycosylation, the protein migrates to 26-36 kDa based on Bis-Tris PAGE result. Endotoxin < 1 EU/μg by the LAL method. Purity > 95% as determined by Bis-Tris PAGE and HPLC Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. Appearance Lyophilized powder Shipping and Storage Transport on ice packs. -25 ~ -15 ° C storage, 1 year expiration date after receipt. After re-solution, store at 2 ~8 °C, 7 days expiration date. After re-dissolution, store at -85~-65°C, 3 months expiration date. Compounding method Centrifuge before opening the lid. Use distilled water to reconstitute lyophilized proteins at reconstitution concentrations greater than 100 μg/mL. it is recommended that proteins be portioned out for each experimental dosage upon first use to avoid repeated freeze-thawing. Cautions 1. For your safety and health, please wear lab coat and disposable gloves. 2. This product is for scientific research purposes only. Documents: Safety Data Sheet 90228_MSDS_HB260228_EN.PDF Manuals 90228_Manual_Ver.EN20260209.pdf
