Interleukin 3 is a pleiotropic factor produced primarily by activated T cells that stimulates the proliferation and differentiation of pluripotent hematopoietic stem cells, as well as various lineage-directed progenitor cells. In addition, IL-3 affects the functional activity of mature mast cells, basophils, eosinophils and macrophages. Due to its diverse functions and targets, it was initially studied under different names, including mast cell growth factor P-cell stimulating factor, burst-promoting activity, multicolony stimulating factor, thy-1 inducing factor, and WEHI-3 growth factor. In addition to activated T cells, other cell types such as human thymic epithelial cells, activated mouse mast cells, mouse keratinocytes, and neuronal/astrocytes also produce IL-3.At the amino acid sequence level, mature human and mouse IL-3 share only 29% sequence identity. This product is supplied as a liquid with high activity, high purity, low endotoxin, and No labeling. Product Properties Synonyms IL3; IL-3; IL-3MGC79398; interleukin 3 (colony-stimulating factor, multiple); interleukin-3; Mast cell growth factor; mast-cell growth factor; MCGF; Species Mouse Source HEK293 Ceslls Sequence Asp33-Cys166 Accession P01586 Tag No Predicted molecularmass 15.1 KDa Endotoxin 95%, determined by SDS-PAGE Activity Measured in a cell proliferation assay using NFS60 mouse myelogenous leukemia lymphoblast cells.The EC50 for this effect is 20-100 pg/mL. Formulation Dissolved in sterile PBS buffer. Appearance Liquid Shipping and Storage -85~-65℃ storage, valid for one year after receipt. Avoid repeated freezing and thawing, centrifuge before opening the bottle. It is recommended to aliquot once for experimental use and freeze at -80℃ after aliquoting. Cautions 1. For your safety and health, please wear lab coat and disposable gloves. 2. This product is for scientific research purposes only.
