IL-11 (interleukin 11) is a pleiotropic cytokine in the IL-6 family, which also includes LIF, CNTF, oncostatin M, cardiotrophin-1, IL-27, and IL-31. In humans, IL-11 has also been found to be an adipogenesis inhibitory factor (AGIF). The aa sequence identity of IL-11 in mature mice with human, rat and canine IL-11 is 88%, 97% and 89%, respectively.IL-11 is secreted by cell types such as osteoblasts, synoviocytes, fibroblasts, chondrocytes, intestinal myofibroblasts, and trophoblasts . It is predominantly present in plasma during inflammation (e.g., inflammation associated with viral infections, cancer, or inflammatory arthritis) and is thought to have primarily anti-inflammatory effects.IL-11 stimulates hematopoiesis and thrombosis, regulates macrophage differentiation, and provides mucosal protection in the intestinal tract. IL-11 has also been found to enhance T-cell polarization to Th2, promote B-cell IgG production, increase osteoclast bone resorption, protect endothelial cells from oxidative stress, and regulate epithelial proliferation and apoptosis. This product is available as Liquid, high activity, high purity, low endotoxin, No labeling. Product Properties Synonyms IL11; IL-11; IL-11Oprelvekin; interleukin 11; interleukin-11; Oprelvekin Species Mouse Source HEK293 Ceslls Sequence Gly23-Leu199 Accession P47873 Tag No Predicted molecularmass 19.1 KDa Endotoxin 95%, determined by SDS-PAGE Activity Measured in a cell proliferation assay using T11 mouse plasmacytoma cells. The EC50 for this effect is 0.04-0.4 ng/mL. Formulation Dissolved in sterile PBS buffer. Appearance Liquid Shipping and Storage -85~-65℃ storage, valid for 1 year after receipt. Avoid repeated freezing and thawing, centrifuge before opening the vial. It is recommended to aliquot for one time experimental use, after aliquoting, -80℃. Cautions 1. For your safety and health, please wear lab coat and disposable gloves. 2. This product is for scientific research purposes only.
