Stem cell factor (SCF), also known as c-kit ligand (KL), mast cell growth factor (MGF), and steel factor (SLF), is a widely expressed 28 - 40 kDa type I transmembrane glycoprotein.SCF promotes the survival, differentiation, and mobilization of a wide range of cell types including myeloid, erythroid, megakaryocyte, lymphoid, germline, and melanocyte progenitors.SCF is the a major growth and activation factor for mast cells and eosinophils. Mouse SCF shares 93% amino acid sequence identity with rat SCF and 72% - 75% amino acid sequence identity with canine, feline and human SCF. Rat SCF is active in mouse and human cells, but human SCF is only weakly active in mouse cells. Non-covalent dimers of transmembrane or soluble SCF interact with the receptor tyrosine kinase SCF R/c-kit to trigger receptor dimerization and signaling. This product is available as Liquid, high activity, high purity, low endotoxin, No labeling. Product Properties Synonyms SCF; SCFStem cell factor; SFc-Kit ligand; SHEP7; SLF; steel factor Species Mouse Source HEK293 Ceslls Sequence Lys26-Ala189 Accession P20826 Tag No Predicted molecularmass 18.3 KDa Endotoxin 95%, determined by SDS-PAGE Activity Measured in a cell proliferation assay using TF1 human erythroleukemic cells. The EC50 for this effect is 2.5-10 ng/mL. Formulation Dissolved in sterile PBS buffer. Appearance Liquid Shipping and Storage -85~-65℃ storage, valid for 1 year after receipt. Avoid repeated freezing and thawing, centrifuge before opening the vial. It is recommended to aliquot for one experimental use, after aliquoting, freeze at -80℃. Cautions 1. For your safety and health, please wear lab coat and disposable gloves. 2. This product is for scientific research purposes only.
