Recombinant Human Lymphocyte Activation Gene 1 Protein/CCL4L1 (Human LAG-1/CCL4L1) _ 90953ES

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LAG-1 is CC chemokine that signals through the CCR5 receptor. LAG-1 is identical to MIP-1β (ACT II isotype) except for two amino acid substitutions; arginine for histidine at posit ion 22 and serine for glycine at position 47 of the mature protein. LAG-1 chemoattracts monocytes, and exhibits activity as an HIV-suppressive factor. Product Properties Synonyms CCL4L1 Accession Q8NHW4 GeneID 388372 Source E.coli-derived Human CCL4L1 protein,Ala24-Asn92. Molecular Weight Approximately7.8 kDa AA Sequence APMGSDPPTA CCFSYTARKL PRNFVVDYYE TSSLCSQPAV VFQTKRGKQV CADPSESWVQ EYVYDLELN Tag None Physical Appearance Sterile Filtered White lyophilized (freeze-dried) powder. Purity > 97% by SDS-PAGE and HPLC analyses. Biological Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human CCR5 transfected murine BaF3 cells is less than 2.0 ng/mL, corresponding to a specific activity of > 5.0 × 105 IU/mg. Endotoxin Show more