RANTES is a CC chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV). Recombinant Mouse RANTES is a 7.9 kDa protein containing 68 amino acid residues, including the four highly conserved cysteine residues present in the CC chemokines. Product Properties Synonyms MuRantes, SIS-delta, Small-inducible cytokine A5, T-cell-specific protein RANTES Accession P97545 GeneID 29397 Source E.coli-derived Mouse RANTES protein,Ser24--Ser91. Molecular Weight Approximately 7.9 kDa. AA Sequence SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS Tag None Physical Appearance Sterile Filtered White lyophilized (freeze-dried) powder. Purity > 97% by SDS-PAGE and HPLC analyses. Biological Activity Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T lymphocytes is in a concentration range of 1.0-10 ng/mL. Endotoxin
