Recombinant Rat VEGF Co-regulated Chemokine 1/CXCL17 (Rat VCC-1/CXCL17) _ 90996ES

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Dendritic cell and monocyte chemokine-like protein (DMC), also known as VEGF-correlated chemokine-1 (VCC-1), is a secreted molecule with a size and predicted three-dimensional fold ing pattern similar to that of chemokines CXCL8/IL-8 and CXCL14/BRAK. It has no predicted N-glycosylation sites, so cleavage of a 22 amino acid (aa) signal sequence likely results in a mature mouse DMC molecule of 97 aa and 11 kDa size. DMC is constitutively produced by airway and intestinal epithelium. It induces the chemotaxis of quiescent, but not LPSactivated peripheral blood monocytes and dendritic cells, and also binds these cells specifically. Product Properties Synonyms Dendritic Cell and Monocyte Chemokine-like Protein, DMC Source E.coli-derived Rat CXCL17 protein,Ser23-Leu119. Molecular Weight Approximately 11.5 kDa AA Sequence SPNQEVARHH GDQHQAPRRW LWEGGQECDC KDWSLRVSKR KTTAVLEPPR KQCPCDHVKG SEKKNRRQKH HRKSQRPSRT CQQFLKRCQL ASFTLPL Tag None Physical Appearance Sterile Filtered White lyophilized (freeze-dried) powder. Purity > 97% by SDS-PAGE and HPLC analyses. Biological Activity Fully biologically active when compared to standard. The ED50 as determined by its ability to induce VEGF expression using murine endothelial cells is less than 5.0 μg/ml, corresponding to a specific activity of > 200 IU/mg. Endotoxin Show more