Biotinylated Human Siglec-3/CD33 Protein, His-Avi Tag

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Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state.They are sialoadhes in/CD169/Siglec-1, CD22/Siglec-2, CD33/Siglec-3, Myelin-Associated Glycoprotein (MAG/Siglec-4a) and Siglecs 5 to 11. To date, no Siglec has been shown to recognized any cell surface ligand other than sialic acids, suggesting that interactions with glycans containing this carbohydrate are important in mediating the biological functions of Siglecs. Specifications Synonyms CD33 molecule; CD33; FLJ00391; gp67; Siglec3; Siglec-3; p67 Uniprot No. P20138-1 Source Recombinant Biotinylated Human Siglec-3/CD33 Protein is expressed from HEK293 Cells with His tag and Avi tag at the C-terminal. It contains Asp18-His259. Molecular Weight The protein has a predicted MW of 29.6 kDa. Due to glycosylation, the protein migrates to 48-58 kDa based on Tris-Bis PAGE result. Physical Appearance Liquid Solution Purity > 95% as determined by SDS-PAGE and > 90% as determined by HPLC Endotoxin < 1.0 EU per 1 μg of the protein by the LAL method. Formulation Supplied as 0.22 μm filtered solution in 20 mM PB, 500 mM NaCl (pH 8.0). Storage The products are shipped with ice pack and can be stored at -80°C for 1 year. Recommend to aliquot the protein into smaller quantities for optimal storage. Please do not repeated freeze-thaw cycles. Note 1.For your safety and health, please wear lab coats and disposable gloves for operation. 2.For research use only! Product Data Show more