Guanylyl Cyclase C (GUCY2C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (GC) family expressed by intestinal epithelial cells from the duodenum to rectum. The ECD of mouse GUCY2C shares 70% and 88% amino acid sequence identity with the ECD of human and rat GUCY2C, respectively. Endogenous ligands of GUCY2C include guanylin and uroguanylin. GUCY2C is also expressed in the brain and is implicated in attention deficiency and hyperactive behavior. Specifications Synonyms Guanylyl cyclase C; GC-C; STAR; GUCY2C; GUC2C; STA receptor; DIAR6; EC 4.6.1; GCC; GUC2CEC 4.6.1.2; MUCIL Uniprot No. Q3UWA6-1 Source Recombinant Biotinylated Mouse GUCY2C/Guanylyl cyclase C Protein is expressed from HEK293 Cells with His tag and Avi tag at the C-terminal. It contains Val20-Met433. Molecular Weight The protein has a predicted MW of 50.01 kDa. Due to glycosylation, the protein migrates to 70-100 kDa based on Tris-Bis PAGE result. Physical Appearance Liquid Solution Purity > 95% as determined by SDS-PAGE and HPLC Endotoxin < 1.0 EU per 1 μg of the protein by the LAL method. Formulation Supplied as 0.22 μm filtered solution in PBS (pH 7.4). Storage The products are shipped with ice pack and can be stored at -80°C for 1 year. Recommend to aliquot the protein into smaller quantities for optimal storage. Please do not repeated freeze-thaw cycles. Note 1.For your safety and health, please wear lab coats and disposable gloves for operation. 2.For research use only! Product Data
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