The epidermal growth factor receptor (EGFR) subfamily of receptor tyrosine kinases comprises four members: EGFR (HER1), ErbB2, ErbB3, and ErbB4. EGFRvIII is tumor specific, and has not been found in normal tissues. EGFRvIII is highly tumorigenic, and can cause aggressive tumor phenotype, with increased invasion, proliferation, angiogenesis, and evasion of apoptosis. Specifications Synonyms ErbB; EC 2.7.10; EC 2.7.10.1; EGFR; mENA; LEGFR; ERBB; ERBB1; HER1; PIG61; NISBD2 Accession NP_001333870.1 Source Recombinant FITC-Labeled Human EGFRVIII Protein is expressed from HEK293 Cells with His tag and Avi tag at the C-terminal. It contains Leu25-Ser378. Molecular Weight The protein has a predicted MW of 41.6 kDa. Due to glycosylation, the protein migrates to 68-80 kDa based on Tris-Bis PAGE result. Purity > 95% as determined by SDS-PAGE. Endotoxin < 1.0 EU per 1μg of the protein by the LAL method. Formulation Supplied as from 0.22μm filtered solution in PBS (pH 7.4). Storage The products are shipped with ice pack and can be stored at -80℃ for 1 year. Recommend to aliquot the protein into smaller quantities for optimal storage. Please avoid freeze-thaw cycles. Note 1.Please operate with lab coats and disposable gloves,for your safety. 2.This product is for research use only. Product Data SDS-PAGE
