A blend of quality neutraceuticals and glycosaminoglycan (GAG) components for the nourishment of joints, cartilage and connective tissues. Contains 8000mg Glucosamine HCI, 1000mg Methylsulfonylmethane (MSM), 3000mg Ascorbic Acid (Vitamin C). The main action of glucosamine on joints is to stimulate the manufacture of substances necessary for joint synthesis. Glucosamine is required by the body for the synthesis of an important family of macromolecules called glycosaminoglycans (GAGs). These long chains of modified sugars (mucopolysaccharides) make up many body tissues including tendons, ligaments and cartilage. Researchers have found that glucosamine is the key precursor for all the various sugars found in (GAG) and further, that glucosamine occupies the pivotal position in connective tissue synthesis by stimulating collagen production.  The lack of glucosamine in the joints may lead to specific tissue weakness. As tissues in the joints become damaged, the lubricating synovial fluid in the joint spaces becomes thin and watery. Therefore the normal cushioning effect within the joint is lost, leaving the bones and cartilage to grind against each other inside the joint space, eventually leading to pain, inflammation and osteoarthritis. Glucosamine HCI has the advantage of being more absorbable than other (GAG) products currently available such as chondroitin sulphate, shark cartilage and N-acetyl-glycosamine (NAG). The molecules in these products are up to 250 times larger than those of Glucosamine HCI, thereby making their absorption far less effective and reliable. HYGAIN® FLEXION® has been formulated with Glucosamine HCI as it contains more glucosamine per molecule than the Glucosamine Sulphate Complex. Proline is an amino acid required for the configuration of the collagen and, in turn, cartilage. Proline is a required component for the production of collagen’s triple helix structure (No Proline, No Collagen). MSM (Methylsulfonylmethane) is reported to create an analgesic and anti-inflammatory effect in response to osteoarthritis. In combination with Glucosamine affects are enhanced.  Ascorbic Acid (Vitamin C) is a co-factor for enzymes involved in collagen stabilisation. Ascorbic Acid is understood to help slow the progression of osteoarthritis.   
