Human HMGB1 (His Tag)

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High-mobility Group Box 1 protein (HMGB1), is a member of the high mobility group box family of non-histone chromosomal proteins. Posttranslational modification of HMGB1, including acetylation, phosphorylation, and methylation, affects HMGB1 localization, receptor interactions, and bioactivity. HMGB1 can be localized to the nucleus or cytoplasm and can also be secreted despite its lack of a signal peptide. HMGB1 can be secreted by multiple cell types, and it is also released upon cell necrosis, apoptosis, and pyroptosis. Specifications Synonyms HMGB1, HMG1, HMG3, SBP-1, HMG-1 Uniprot No. P09429-1 Source Recombinant Human HMGB1 Protein is expressed from HEK293 Cells with His tag at the C-terminal. It contains Met1-Glu215. Molecular Weight Approximately 26 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Tris-Bis PAGE result. Purity > 95% as determined by SDS-PAGE. Endotoxin Show more