A Simple PBPK Model (Team)

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In this series of exercises, you will learn how to create a PBPK model of midazolam, a widely used sedative, approved as premedication before surgical interventions. More specifica lly you learn how to:1. Utilize in vitro data2. Perform sensitivity analysis of the model3. Optimize the model with parameter identification4. Compare simulation results with observed dataThe exercises are based on the published PBPK model of midazolam:Hanke N. et al. CPT Pharmacometrics Syst. Pharmacol. (2018) 7, 647–659 Show more