acetylcholine ring | sterling silver The first neurotransmitter ever discovered. Otto Loewi proved its existence in 1921 with an elegant experiment: collecting fluid from a stimulated frog heart and transferring it to a resting heart, which then slowed. That experiment earned the 1936 Nobel Prize and launched modern neuroscience. The Science Behind Acetylcholine Acetylcholine (ACh) is synthesized from choline and acetyl-CoA by choline acetyltransferase and hydrolyzed rapidly after release by acetylcholinesterase. It acts on two receptor types: nicotinic receptors (ligand-gated ion channels at the neuromuscular junction and autonomic ganglia) and muscarinic receptors (GPCRs in the heart, glands, and CNS). In the central nervous system, cholinergic neurons from the basal forebrain project widely to the cortex and hippocampus, modulating attention and memory. The selective loss of these neurons in Alzheimer's disease underlies much of the cognitive decline. This cholinergic hypothesis led directly to acetylcholinesterase inhibitors (donepezil, rivastigmine, galantamine) as the primary symptomatic treatment. A Meaningful Gift for Science Lovers neuroscientists studying cholinergic systems neurologists treating Alzheimer's disease or myasthenia gravis pharmacologists working with nicotinic or muscarinic receptors neuroscience students interested in the history of the field For the neurologist who prescribes acetylcholinesterase inhibitors and can explain exactly why. Explore Related Molecules Jewelry Dopamine Ring | silver GABA Ring | silver Serotonin Ring | silver Noradrenaline Necklace | silver FAQ Why is acetylcholine historically so important? Loewi's Vagusstoff experiment in 1921 provided the first direct evidence that the nervous system uses chemical messengers, not just electrical signals. This single discovery launched modern neuroscience. Every time a neurotransmitter is discussed in a classroom, Loewi is there. What do you give a neuroscientist on their first day at the lab? Acetylcholine. The molecule Otto Loewi proved actually exists. A neuroscientist, neurologist, or pharmacologist recognizes this molecule immediately and understands its history. What are the size and material? How do I determine my ring size? Sterling silver acetylcholine ring, available in US sizes 5-9. 925 polished sterling silver, nickel-free and hypoallergenic. To determine size, wrap a strip of paper around the base of your finger and mark where it overlaps. Measure in millimetres and reference a ring-size conversion chart, or contact us for guidance. All import duties and taxes are covered by Science Jewelry 18:24. Can I return it if the fit isn't right? Yes. All jewelry is covered by a 30-day “Love It or Return It” policy. If the size or fit doesn't work, we will help you find the right option.
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