ACIDOSTAT
ACIDOSTAT based on sodium alginate, carbonate and bicarbonate. Sodium alginate - Extracted from seaweed Unique properties used in GERD*; Heartburn; Regurgitation Interacts with the acids (HCl) in the stomach It forms a gel-like substance (raft) – see image A It floats on top of the stomach content and acts as a physical barrier It prevents the acid from rising into the esophagus It acts very quickly (in minutes) for immediate relief In combination with different types of carbonates, after CO2 (carbon dioxide) release, alginate captures CO2 bubbles so it has a lower density than the contents of the stomach and will float for a long time with prolonged effect – Image B *GERD = Gastroesophageal Reflux Disease Reference Raja Ali, Raja Affendi & Hassan, Jamiyah & Egan, Laurence. (2022). Review of recent evidence on the management of heartburn in pregnant and breastfeeding women. BMC Gastroenterology. 22. 10.1186/s12876-022-02287-w. Kim HM. Raft Formation of Sodium Alginate in the Stomach. J Neurogastroenterol Motil. 2016 Oct 30;22(4):705-706. doi: 10.5056/jnm16068. PMID: 27605509; PMCID: PMC5056581. Image A Referință imagine A: Ali, R.A.R., Hassan, J. & Egan, L.J. Review of recent evidence on the management of heartburn in pregnant and breastfeeding women. BMC Gastroenterol 22, 219 (2022). https://doi.org/10.1186/s12876-022-02287-w Raft formation – sodium alginate Image B Referință imagine B: Kim HM. Raft Formation of Sodium Alginate in the Stomach. J Neurogastroenterol Motil. 2016 Oct 30;22(4):705-706. doi: 10.5056/jnm16068. PMID: 27605509; PMCID: PMC5056581. Calcium carbonate (CaCO3) • It is an antacid • It reacts with gastric acid (HCl) • Improves the motor function of the esophagus, thereby improving acid clearance from the esophagus to the stomach • It provides 120 minutes of acid neutralization (long lasting effect) • 15-30% of calcium is absorbed (good source for calcium intake) Sodium carbonate (Na2CO3) It is an antacid with slower and prolonged effect It is a strong basic inorganic salt that acts by neutralizing hydrochloric acid in the stomach It has cytoprotective effects Released CO2 increases the effect of alginate Sodium bicarbonate (NaHCO3) It is an antacid with very rapid action It acts by neutralizing hydrochloric acid in the stomach quickly, thus reducing symptoms very fast (minutes) It has cytoprotective effects Released CO2 increases the effect of alginate Reference: Garg V, Narang P, Taneja R. Antacids revisited: review on contemporary facts and relevance for self-management. J Int Med Res. 2022 Mar;50(3):3000605221086457. doi: 10.1177/03000605221086457. PMID: 35343261; PMCID: PMC8966100. Pregnancy and lactation • At the recommendation of the healthcare specialist, it is possible to administer the lowest effective dose: • ½ or 1 tablet, as needed, without exceeding 3 tablets per day, for maximum 5 days Proton pump inhibitors (PPI) • Since PPIs have a maximum effect after 3-5 days, simultaneous administration of ACIDOSTAT is recommended for the rapid reduction of symptoms for 5 days • After the first 5 days of PPI treatment, ACIDOSTAT can be administred as needed, while continuing with PPI Potential drug interactions • Due to the calcium content, simultaneous administration with some drugs is avoided: fluoroquinolones, tetracyclines, digoxin, iron salts, biphosphonates, PPI, thyroid hormones etc. To eliminate interactions, drugs are administered two hours apart from ACIDOSTAT When and how to take ACIDOSTAT • Recommended in gastric hyperacidity, acid reflux and poor digestion with hyperacidity • Usually take 1-2 tablets, as needed, when the symptoms are bothersome • Not to exceed a maximum of 6 tablets per day • The tablets are allowed to dissolve slowly in the oral cavity, or it can be crushed and swallowed • Do not use in children under 6 years of age and for more than five days continuously. Why ACIDOSTAT Transforms irritating gastric acid into harmless water and CO2 in just a few minutes Proven raft formation in human subjects (anti-reflux effect) It contains fast- and slow acting antacids in combination with alginate – triple effect It protects the gastric mucosa Antiacid and anti-reflux effects Has rapid effect with prolonged action (2-6 hours) Can be used by children above 6 years of age, pregnant people, lactating women and by diabetic patients (no sugar) Synergistic active ingredients INSTRUCTIONS FOR USE Take 1-2 tablets in case of gastric hyperacidity. FUNCTIONAL INGREDIENTS: Bulking agent: sorbitol*; sodium alginate; calcium carbonate; sodium bicarbonate; sodium carbonate; anti-caking agents; silicon dioxide, magnesium salts of fatty acids; flavor; sweetener: sucralose. Presentation: 20 tablets Active ingredients: Active substances Per one tablet Sodium alginate 250 mg Calcium carbonate • Calcium 133.50 mg • 80.14 mg %Daily Value – To be completed Sodium bicarbonate 133.50 mg Sodium carbonate 133.50 mg Sorbitol Sweetener 0.75 kcal DETALII: FORMAT 20 tablets of 1000 mg CODE EAN 0803173153128