This unique blend of nutrients, herbs and adaptogens supports normal adrenal function during occasional stress and fatigue. Clinical Applications Improves Stress Resilience Supports Healthy Energy Levels Strengthens the Body’s Stress Response Improves Mental and Physical Performance Helps Maintain a Balanced Cortisol-to-DHEA Ratio Stress is defined as any disturbance–extreme cold or heat, psychological stress, sleep deprivation, work overload, physical trauma, as well as toxic exposure- that can trigger the stress response. The body’s stress response system is comprised of the hypothalamic-pituitary-adrenal (HPA) axis. Rhodiola rosea Root Extract Rhodiola rosea has been categorized as an adaptogenic botanical due to its ability to increase resistance to a variety of stressors. Rhodiola has been studied extensively and is widely used in Eastern Europe and Asia to help support the nervous system, mood regulation, mental clarity, work performance and the sleep cycle. Within the central nervous system, Rhodiola has demonstrated an ability to preserve levels of neurotransmitters such as serotonin, dopamine and norepinephrine. In a randomized, double blind placebocontrolled study examining the effects of Rhodiola on fatigue and stress, 161 patients aged 19 to 21 years received 185 mg of Rhodiola twice daily resulting in a significant reduction in fatigue. An additional study using Rhodiola extract in students showed significant improvements in mental performance, greater mood stability, and improved sleep patterns. Eleuthero Root Extract Eleutherococcus senticosus has been identified as a strong adaptogenic botanical and is widely used in China to improve general health, support memory and physical endurance. In addition to its ability to improve stress resilience and maintain energy, Eleuthero has been shown to support the immune system. In a double-blind study, the adaptogenic effects of Eleuthero were demonstrated as volunteers receiving Eleuthero maintained a sense of calmness, reflected by a reduction of heart rate, during stress exposure. Eleuthero has also been shown to improve performance in runners. In a study on performance athletes, Eleuthero extract (2 or 4 mL) given 30 minutes prior to a race significantly reduced race time (48.7 minutes) compared to the control group (52.6 minutes). Schisandra Berry Extract Schisandra is an adaptogenic botanical that has been used for centuries in China and Russia to help support mental clarity, stress response and emotional wellness. In a double-blind, placebo-controlled study, athletes were given Schisandra chinensis and Bryonia alba extracts or placebo. Those receiving the therapy had increased concentrations of nitric oxide, a molecule which causes the blood vessels to expand resulting in increased circulation, increased blood flow and nutrients throughout the body. The researchers concluded that Schisandra provides supportive factors for physical performance in athletes. Schisandra berry has been shown to support learning and memory and may have some protective factors that support brain health. Licorice Root Extract The primary components in licorice root that support adrenal health include glycyrrhetic acid and glycyrrhizin. Licorice has also been shown to block 11-ß-hydroxysteroid dehydrogenase, the enzyme responsible for the conversion of cortisol to the inactive cortisone. When taken in small doses, licorice root extract can be used to maintain normal cortisol levels, an important factor for individuals that need to support adrenal hormone production and maintain healthy inflammatory pathways. Ashwagandha Root Extract Ashwagandha’s strong adaptogenic properties provide an array of benefits for individuals that have compromised health due to extreme stress exposure. Ashwagandha’s benefits include improving stress resilience, supporting immune response, regulating the sleep cycle, supporting healthy thyroid function and protecting against exhaustion of the nervous system. Ashwagandha has also been shown to be beneficial in supporting proper mood regulation and restoring a sense of calmness under stress. Micronutrient Blend Adapten-All® contains a combination of micronutrients that are crucial for buffering the effects of stress and supporting adrenal gland function. Pantothenic acid (vitamin B5) helps support adrenal gland function. Pantothenic acid also breaks down in the body into coenzyme A, which plays a large part in energy (ATP) production. Vitamin B6 is a required cofactor for the synthesis of several neurotransmitters that help buffer stress including serotonin, GABA, and dopamine. Vitamin B12 (methylcobalamin) helps to reset the circadian rhythm of cortisol excretion throughout the day. Vitamin C is a vital nutrient for adrenal gland function. Vitamin C levels are among the highest in the adrenal glands compared to other organs and urinary excretion of vitamin C is elevated during times of stress. Supplementation with vitamin C supports the health of the adrenal glands and also supports immune function.
