Ortho Molecular Adren-All Endocrine Health The special blend of vitamins and adaptogenic herbs in Adren-All® supports normal adrenal function during occasional stress and fatigue. Adren-All® contains a blend of key micronutrients, adaptogenic botanicals, and adrenal concentrate specifically formulated to strengthen the body’s stress response and support healthy energy levels. Adren-All® provides targeted amounts of vitamin A and C, pantothenic acid, and other B vitamins that are critical to adrenal gland function. This powerful formulation helps support the body’s resistance to fatigue and aids in maintaining balanced cortisol and DHEA levels. Stress is defined as any disturbance–extreme cold or heat, psychological stress, sleep deprivation, work overload, physical trauma, as well as toxic exposure- that can trigger the stress response. The body’s stress response system is comprised of the hypothalamic-pituitary-adrenal (HPA) axis. Prolonged stress triggers the HPA axis and consists of three stages: stage 1: alarm; stage 2: resistance; and stage 3: exhaustion. The initial, short-lived phase (the alarm phase) is the body’s normal fight-or-flight response to danger, which is characterized by elevated cortisol levels. The next phase, the resistance phase, allows the body to continue buffering extended stress exposure, long after the initial fight-or-flight response has dissipated. Hormones released by the adrenals, such as cortisol and DHEA, help support the "resistance" reaction. However, extended periods of stress not only burden the system, creating an imbalance in cortisol and DHEA production, but can result in mental and physical fatigue, nervous tension, irritability, and poor memory-all of which are characteristic of stage 3. Adren-All® offers a unique blend of botanicals, adrenal concentrate, and micronutrients that support the adrenal glands, as well as the body’s ability to respond to and counteract the negative effects of stress. Key Benefits and Features: Improves Stress Resilience Supports Healthy Energy Levels Strengthens the Body’s Stress Response Improves Mental and Physical Performance Helps Maintain a Balanced Cortisol-to-DHEA ratio Ingredients Serving Size: 2 Capsules Amount/Serving Vitamin A (from 500 IU as Natural Beta Carotene) 150 mcg Vitamin C (as Ascorbic Acid USP) 200 mg Vitamin E (from 200 IU as d-Alpha Tocopherol Succinate USP) 13.4 mg Niacin USP 20 mg Vitamin B6 (as Pyridoxine Hydrochloride USP, Pyridoxal 5'-Phosphate) 30 mg Vitamin B12 (as Methylcobalamin) 200 mcg Pantothenic Acid (as d-Calcium Pantothenate USP) 350 mg Calcium 30 mg Adrenal Concentrate (Bovine) 220 mg Eleuthero Root Extract (Standardized to contain 0.8% Eleutherosides) 100 mg Rhodiola (Rhodiola rosea) Root Extract (Standardized to contain 3% Rosavins) 100 mg Schisandra Berry Extract 100 mg Chinese Licorice Root Extract (Standardized to contain 12% Glycyrrhizin) 75 mg Other Ingredients: None. Does Not Contain: Wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, or preservatives. Suggested Use Take 2 capsules one or two times per day, or as recommended by your healthcare professional. Warning: Do not consume this product if you are pregnant or nursing. Keep out of the reach of children. Storage: Keep tightly closed in a cool, dry place. More Info. Rhodiola rosea Root Extract Rhodiola rosea has been categorized as an adaptogenic botanical due to its ability to increase resistance to a variety of stressors. Rhodiola has been studied extensively and is widely used in Eastern Europe and Asia to help support the nervous system, mood regulation, mental clarity, work performance, and the sleep cycle. Within the central nervous system, Rhodiola has demonstrated an ability to preserve levels of neurotransmitters such as serotonin, dopamine, and norepinephrine. In a randomized, double-blind, placebo- controlled study examining the effects of Rhodiola on fatigue and stress, 161 patients aged 19 to 21 years received Rhodiola twice daily, resulting in a significant reduction in fatigue. An additional study using Rhodiola extract in students showed significant improvements in mental performance, greater mood stability, and improved sleep patterns. Eleuthero Root Extract Eleutherococcus senticosus has been identified as a strong adaptogenic botanical and is widely used in China to support general health, memory, and endurance. In addition to its ability to improve stress resilience and fight fatigue, Eleuthero has exhibited immune-supporting effects.5 In a double -blind study, 45 healthy volunteers received Eleuthero or a placebo for 30 days. A cognitive challenge test was given to assess stress response and heart rate. Unlike a placebo, subjects receiving Eleuthero demonstrated a 40% reduction in heart rate in response to the stressor.6 Eleuthero has also been shown to improve performance in runners. In a study on performance athletes, Eleuthero extract (2 or 4 mL) given 30 minutes prior to a race significantly reduced race time (48.7 minutes) compared to the control group (52.6 minutes). Schisandra Berry Extract Schisandra berry extract is an adaptogenic botanical that has been used for centuries in China and Russia to help support mental clarity, stress response, and emotional wellness. In a double-blind, placebo-controlled study, athletes who were given an adaptogenic blend including Schisandra chinensis extract or a placebo had increased concentrations of nitric oxide, a molecule that causes the blood vessels to expand, resulting in increased circulation, increased blood flow and nutrients throughout the body, and healthy blood pressure.8 The researchers concluded that Schisandra berry enhances physical performance in athletes. Schisandra berry has also been shown to support learning and memory and may have a protective effect on brain health. Licorice Root Extract The primary components in licorice root that support adrenal health include glycyrrhetic acid and glycyrrhizin. Licorice has also been shown to block 11-β-hydroxysteroid dehydrogenase, the enzyme responsible for the conversion of cortisol to the inactive cortisone. When taken in small doses, licorice root extract can be used to maintain cortisol levels, an important factor for individuals who need to support adrenal hormone production and maintain healthy inflammatory pathways. Adrenal Concentrate For thousands of years, glandular concentrates have been used in medicine to supply key nutrients to support the body. The concept of glandular therapy states that similar organ extracts from animals will support the same organ within humans by stimulating its activity. Adrenal bovine concentrate allows for rejuvenation of the adrenal stress system in a balanced and efficient manner. Micronutrient Blend Adrenal gland function, as well as the synthesis of cortisol, is dependent on an adequate supply of several vitamins. Vitamin C plays a major role in neurotransmitter production and supports general health of the adrenals. Under the stressful conditions, vitamin C and B complex vitamins are readily used and excreted from the body. Within the B vitamin family, pantothenic acid breaks down into Coenzyme A, which is essential for the production of energy from ingested carbohydrates, fats, and proteins. In a study evaluating the effects of pantothenic acid and glutathione production, pantothenic acid was found to increase CoA levels in the body, leading to increased ATP production. Niacin also plays a vital role in many metabolic functions in the body, including supplying energy to cells and assisting in the production of adrenal hormones.
