Thorne Advanced Bone Support (Formerly Oscap) An advanced bone formula with calcium and vitamin D per capsule for added bone support. Advanced Bone Support contains more calcium, magnesium, and vitamin D per capsule than the previous formula. In addition it provides B vitamins for healthy methylation, and boron – all to support bone health. Ingredients Serving Size: 2 Capsules Amount/Serving Vitamin D (as Vitamin D3)(1,000 IU) 25 mcg Vitamin B6 (as Pyridoxal 5'-Phosphate) 20 mg Folate (100 mcg as L-5 Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) 166.6 mcg DFE Vitamin B12 (as Methylcobalamin) 50 mcg Calcium (as DimaCal® DiCalcium Malate)†† 300 mg Magnesium (as Albion® DiMagnesium Malate)††† 100 mg Boron (as Bororganic™ Boron Glycinate Complex)†††† 3 mg Other Ingredients: Hypromellose (derived from cellulose) Capsule, Medium Chain Triglycerides Oil. Gluten Free. †This product uses Gnosis S.p.A.’s L-5-Methyltetrahydrofolic Acid, Glucosamine Salt (Quatrefolic®). Quatrefolic is a registered trademark of Gnosis S.p.A. ††This product uses DimaCal® DiCalcium Malate. DimaCal is a registered trademark of of Albion International, Inc.†††This product uses Albion’s DiMagnesium Malate. Albion is a registered trademark of Albion International, Inc. ††††This product uses Albion’s Bororganic™ Boron Glycinate Complex. Bororganic is a trademark of Albion International, Inc. Suggested Use Take 2 capsules two times daily or as recommended by a health-care practitioner. ALLERGY WARNING This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients. PREGNANCY If pregnant, consult your health-care practitioner before using this product. INTERACTIONS 5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, this folate source has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate. More Info. Although everyone loses bone density as they age, certain groups are particularly at risk. As many as half of all women in the United States older than 65 should be concerned about maintaining good bone health. Thorne's Advanced Bone Support is a comprehensive bone support supplement. It contains dicalcium malate and dimagnesium malate (two calcium or magnesium molecules each bound to one molecule of malic acid) for enhanced absorption and greater concentration of these important minerals. Adequate magnesium intake promotes bone density by optimizing the secretion of parathyroid hormone and facilitating active calcium transport to the bones. Advanced Bone Support provides vitamin D3, which facilitates the absorption of calcium; boron, which assists the body's metabolism of vitamin D and estrogen; and B vitamins for healthy methylation, which mediates homocysteine levels, a known risk factor of low bone density. Research indicates that an elevated homocysteine level in the blood can interfere with the integrity of the bone matrix. Therefore, Advanced Bone Support contains methylcobalamin (an active form of vitamin B12), L-5-methyltetrahydrofolate (the active form of folic acid), and pyridoxal 5'-phosphate (the active form of vitamin B6) for their function in helping to maintain already normal homocysteine levels. To provide a bone health formula that can be used by individuals taking a blood-thinning medication, Advanced Bone Support does not contain vitamin K. As women age, they experience an overall increase in bone loss compared to bone formation, so a woman's concern about maintaining good bone health should begin well before menopause. Because some bone loss during menopause is inevitable, more bone a woman has "banked" earlier in life, the greater her peak bone mass as she begins to age. Hence, menopausal bone loss will have less of an adverse impact. Even women in the 18-35 year-old age group should make an effort to achieve good bone health, because physical inactivity, low body weight, eating disorders, and poor nutrition during these ages can have adverse impacts on bone health later in life. Groups at particular risk for bone loss in addition to women include smokers, those with a sedentary lifestyle, individuals who consume excessive sugar, alcohol, or caffeine, small-boned individuals, Caucasians, Asians, and patients on steroid or anticonvulsant therapies for prolonged periods of time.
