Advanced NAD & NADshield: NNMT Inhibitor for NAD+ Protection and Longevity By RevGenetics
Third-party lab tested, every batch. View this batch's Certificate of Analysis Boosting NAD+ is only half the battle. Your body burns through it via the NNMT enzyme, so most of the gain slips away. Advanced NAD & NADshield helps you boost NAD+ and then protect it with NNMT-inhibitor technology. NADshield NNMT inhibitor, helps protect the NAD+ you make, not just boost it Public COA, third-party tested, made in the USA Supports healthy NAD+ levels for steady cellular energy* *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Try Advanced NAD for 30 days, the risk is on us. Advanced NAD is third-party tested, backed by a public Certificate of Analysis, and made in the USA, covered by our 30-day guarantee. Choose your option above and start today. Third-Party Tested • Public COA • Made in USA • 30-Day Guarantee /* Scoped CSS for Advanced NAD - All classes prefixed with rg-advnad- */ .rg-advnad-wrapper { max-width: 1400px; margin: 0 auto; padding: 20px; font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Oxygen, Ubuntu, sans-serif; line-height: 1.7; color: #333; } .rg-advnad-article { background: #fff; } .rg-advnad-article h1 { font-size: 1.9em; line-height: 1.3; margin-bottom: 20px; color: #b02810; } .rg-advnad-article h2 { font-size: 1.5em; margin-top: 40px; margin-bottom: 15px; color: #d33313; border-bottom: 2px solid #d33313; padding-bottom: 8px; } .rg-advnad-article h3 { font-size: 1.2em; margin-top: 25px; margin-bottom: 12px; color: #e74c3c; } .rg-advnad-article p { margin-bottom: 16px; } /* Hero Section */ .rg-advnad-hero { background: linear-gradient(135deg, #fff5f5 0%, #fee2e2 100%); padding: 30px; border-radius: 12px; margin-bottom: 30px; border: 2px solid #fecaca; text-align: center; } .rg-advnad-hero-content { display: grid; grid-template-columns: 1fr 1fr; gap: 30px; align-items: center; margin: 20px 0; } .rg-advnad-hero-img { width: 100%; max-width: 350px; height: auto; border-radius: 12px; box-shadow: 0 8px 24px rgba(211, 51, 19, 0.15); margin: 0 auto; } .rg-advnad-absorption-box { background: linear-gradient(135deg, #f0f9ff 0%, #dbeafe 100%); padding: 25px; border-radius: 12px; border: 2px solid #3b82f6; text-align: center; } .rg-advnad-absorption-number { font-size: 3.5em; font-weight: bold; color: #1d4ed8; margin: 10px 0; } /* Author Bio */ .rg-advnad-author-bio { background: #f8f9fa; border: 1px solid #e9ecef; border-radius: 8px; padding: 20px; margin: 25px 0; } .rg-advnad-author-inner { display: flex; gap: 15px; align-items: flex-start; } .rg-advnad-author-img { width: 60px; height: 60px; border-radius: 50%; object-fit: cover; flex-shrink: 0; border: 2px solid #d33313; } .rg-advnad-author-name { font-weight: 600; font-size: 1.05em; margin: 0 0 5px 0; } .rg-advnad-author-name a { color: #b02810; text-decoration: none; } .rg-advnad-author-desc { font-size: 0.9em; color: #555; margin: 0; } .rg-advnad-author-creds { font-size: 0.85em; color: #666; margin-top: 12px; padding-top: 12px; border-top: 1px solid #ddd; } .rg-advnad-author-date { font-size: 0.85em; color: #666; margin-top: 8px; } /* Summary Box */ .rg-advnad-summary { background: linear-gradient(135deg, #fff5f5 0%, #fee2e2 100%); padding: 20px; border-radius: 8px; margin: 20px 0; border-left: 4px solid #d33313; } /* Protocol Box - NEW for HowTo rich snippet */ .rg-advnad-protocol { background: linear-gradient(135deg, #ecfdf5 0%, #d1fae5 100%); border: 2px solid #10b981; border-radius: 12px; padding: 25px; margin: 25px 0; } .rg-advnad-protocol h3 { color: #065f46; margin-top: 0; } .rg-advnad-protocol-list { counter-reset: protocol-counter; list-style: none; padding: 0; margin: 15px 0; } .rg-advnad-protocol-list li { counter-increment: protocol-counter; padding: 15px 0 15px 55px; border-bottom: 1px solid #a7f3d0; position: relative; font-size: 1.05em; } .rg-advnad-protocol-list li::before { content: counter(protocol-counter); position: absolute; left: 0; top: 50%; transform: translateY(-50%); width: 38px; height: 38px; background: #10b981; color: white; border-radius: 50%; display: flex; align-items: center; justify-content: center; font-weight: bold; } .rg-advnad-protocol-list li:last-child { border-bottom: none; } .rg-advnad-protocol-note { background: #d1fae5; padding: 15px; border-radius: 8px; margin-top: 15px; font-size: 0.95em; } /* NNMT Explainer Box - Critical Visual */ .rg-advnad-nnmt-explainer { background: linear-gradient(135deg, #fef3c7 0%, #fde68a 100%); border: 2px solid #f59e0b; border-radius: 12px; padding: 25px; margin: 30px 0; } .rg-advnad-nnmt-title { font-size: 1.3em; font-weight: bold; color: #92400e; margin-bottom: 15px; text-align: center; } .rg-advnad-pathway-visual { display: grid; grid-template-columns: 1fr auto 1fr; gap: 15px; align-items: center; margin: 20px 0; text-align: center; } .rg-advnad-pathway-box { background: white; border-radius: 8px; padding: 15px; border: 2px solid #e5e7eb; } .rg-advnad-pathway-good { border-color: #10b981; background: #ecfdf5; } .rg-advnad-pathway-bad { border-color: #ef4444; background: #fef2f2; } .rg-advnad-pathway-arrow { font-size: 2em; color: #6b7280; } /* Comparison Table - Critical for SEO */ .rg-advnad-comparison-table { width: 100%; border-collapse: collapse; margin: 25px 0; background: white; border-radius: 10px; overflow: hidden; box-shadow: 0 4px 15px rgba(211, 51, 19, 0.1); font-size: 0.95em; } .rg-advnad-comparison-table th { background: #d33313; color: white; padding: 14px 12px; text-align: left; font-weight: 600; } .rg-advnad-comparison-table th.rg-advnad-th-center { text-align: center; } .rg-advnad-comparison-table td { padding: 12px; border-bottom: 1px solid #e9ecef; } .rg-advnad-comparison-table td.rg-advnad-td-center { text-align: center; } .rg-advnad-comparison-table tr:nth-child(even) { background-color: #fff5f5; } .rg-advnad-comparison-table tr:hover { background-color: #fee2e2; } .rg-advnad-comparison-table .rg-advnad-highlight-row { background: #ecfdf5 !important; font-weight: 600; } .rg-advnad-comparison-table .rg-advnad-highlight-row:hover { background: #d1fae5 !important; } .rg-advnad-good { color: #059669; font-weight: 600; } .rg-advnad-bad { color: #dc2626; } .rg-advnad-neutral { color: #6b7280; } /* Benefits Grid */ .rg-advnad-benefits-grid { display: grid; grid-template-columns: repeat(auto-fit, minmax(280px, 1fr)); gap: 20px; margin: 25px 0; } .rg-advnad-benefit-card { background: #fff5f5; padding: 20px; border-radius: 10px; border-left: 4px solid #d33313; box-shadow: 0 4px 12px rgba(211, 51, 19, 0.1); } .rg-advnad-benefit-card h4 { color: #b02810; margin: 0 0 10px 0; font-size: 1.1em; } .rg-advnad-benefit-card p { margin: 0; font-size: 0.95em; } /* Two Column Layout */ .rg-advnad-two-col { display: grid; grid-template-columns: 1fr 1fr; gap: 30px; align-items: start; margin: 25px 0; } /* Research Note */ .rg-advnad-research-note { background: #e3f2fd; border: 1px solid #90caf9; border-radius: 8px; padding: 15px; margin: 20px 0; } .rg-advnad-research-title { font-weight: bold; color: #1565c0; } .rg-advnad-research-cite { font-size: 0.85em; color: #666; font-style: italic; margin-top: 10px; } /* Chart Images */ .rg-advnad-chart-img { width: 100%; max-width: 500px; height: auto; border-radius: 8px; box-shadow: 0 4px 12px rgba(0,0,0,0.1); margin: 15px auto; display: block; } /* Key Takeaway */ .rg-advnad-keytakeaway { background: #ecfdf5; padding: 15px 20px; border-radius: 8px; margin: 20px 0; border-left: 4px solid #10b981; } /* Ingredient Box */ .rg-advnad-ingredient-box { background: #fff7ed; padding: 25px; border-radius: 12px; margin: 25px 0; border: 2px solid #fb923c; } /* FAQ Section */ .rg-advnad-faq-section { background: #f8f9fa; padding: 30px; border-radius: 15px; margin: 30px 0; border: 1px solid #dee2e6; } .rg-advnad-faq-grid { display: grid; grid-template-columns: repeat(auto-fit, minmax(400px, 1fr)); gap: 20px; } .rg-advnad-faq-item { background: white; padding: 20px; border-radius: 10px; border-left: 4px solid #d33313; } .rg-advnad-faq-question { font-weight: bold; color: #b02810; margin-bottom: 10px; font-size: 1.05em; } .rg-advnad-faq-answer { color: #555; line-height: 1.7; font-size: 0.95em; } /* References */ .rg-advnad-references { font-size: 0.9em; margin-top: 30px; } .rg-advnad-references ol { padding-left: 20px; } .rg-advnad-references li { margin-bottom: 10px; color: #555; } .rg-advnad-references a { color: #1565c0; } /* Footer */ .rg-advnad-footer { background: #f8f9fa; padding: 20px; border-radius: 8px; margin-top: 40px; font-size: 0.9em; } .rg-advnad-disclaimer { font-size: 0.85em; color: #666; font-style: italic; margin-top: 15px; padding-top: 15px; border-top: 1px solid #ddd; } /* Internal Links */ .rg-advnad-internal-link { color: #b02810; text-decoration: none; border-bottom: 1px dotted #b02810; } .rg-advnad-internal-link:hover { border-bottom-style: solid; } /* Voice SEO Hidden */ .rg-advnad-voice-seo { position: absolute; left: -9999px; width: 1px; height: 1px; overflow: hidden; } /* Responsive */ @media (max-width: 768px) { .rg-advnad-wrapper { padding: 15px; } .rg-advnad-article h1 { font-size: 1.5em; } .rg-advnad-hero-content { grid-template-columns: 1fr; } .rg-advnad-two-col { grid-template-columns: 1fr; } .rg-advnad-faq-grid { grid-template-columns: 1fr; } .rg-advnad-comparison-table { font-size: 0.85em; } .rg-advnad-comparison-table th, .rg-advnad-comparison-table td { padding: 8px 6px; } .rg-advnad-author-inner { flex-direction: column; } .rg-advnad-absorption-number { font-size: 2.5em; } .rg-advnad-pathway-visual { grid-template-columns: 1fr; } .rg-advnad-pathway-arrow { transform: rotate(90deg); } } Advanced NAD with NADShield: Revolutionary NNMT Protection Technology Rapid Absorption Technology 30 min Fast NAD Precursor Delivery+ NNMT Inhibitor Protectionvs. 8+ hours for standard supplements Advanced NAD with NADShield is the first NAD supplement to combine rapid 30-minute absorption with natural NNMT inhibitor protection. While standard NAD supplements lose effectiveness to NNMT enzyme degradation, NADShield protects your NAD precursors using vanillin (4-Hydroxy-3-methoxybenzaldehyde), ensuring maximum cellular utilization. Anthony Loera, Founder & CEO of RevGenetics This guide explains the science behind NNMT inhibition and NAD protection, plus the optimized usage protocol for maximizing your NAD+ shield. Anthony has formulated longevity supplements since 2007 and developed NADShield after reviewing research on NNMT's role in NAD degradation. About Anthony: Founded RevGenetics in 2007 | 19+ years in longevity supplement formulation | Pioneer in NAD optimization technologies | Learn more Last Updated: January 7, 2026 The NAD Degradation Problem: Standard NAD supplements face a hidden challenge: the NNMT enzyme actively breaks down NAD precursors before they can be converted to usable NAD+. Research shows NNMT activity increases with aging, worsening this problem. Advanced NAD with NADShield solves this by incorporating natural NNMT inhibitors that protect your NAD investment, ensuring precursors reach their cellular targets intact. Maximizing Your NAD+ Shield: Usage Guide (2026) The NADShield technology translates complex NNMT science into practical benefits. Follow this protocol to maximize your NAD+ protection: Step-by-Step Protocol for Maximum NNMT Protection Hydration for Rapid Dissolution: Take with a full glass of water (8-12 oz) to ensure rapid dissolution of the capsule in the stomach. This activates the 30-minute absorption technology and delivers NAD precursors quickly to cells. Morning or Evening Timing: Take in the morning for daytime cellular energy support, or in the evening for cellular repair during sleep. The 30-minute absorption allows flexible timing based on your goals. Safe Stacking with Other NAD Precursors: Safe to combine with NMN or additional resveratrol supplements. The vanillin-based NNMT inhibitor operates independently to clear the metabolic pathway for all NAD precursors you take. Daily Steady-State Maintenance: Take 1 capsule daily for continuous NNMT suppression. Unlike the pulse dosing of senolytics like fisetin, NADShield requires steady-state administration to keep NNMT enzyme levels consistently suppressed. Long-Term Optimization: Continue daily use for ongoing NAD+ protection. NNMT activity increases with age, making consistent supplementation increasingly important for maintaining optimal NAD+ levels over time. ⚡ Key Difference from Senolytics: While fisetin uses a "pulse" protocol (5 days/month), NADShield requires daily steady-state dosing because NNMT is continuously active. Skipping days allows NNMT activity to resume, degrading your NAD precursors. Pro Tip: If stacking with NMN, the vanillin in NADShield clears the metabolic pathway for both supplements simultaneously. Take together in the morning with a full glass of water for maximum synergy. Understanding NNMT: The Hidden Barrier to NAD Supplement Effectiveness 🔬 The NNMT Problem: Why Standard NAD Supplements Underperform NNMT (Nicotinamide N-methyltransferase) is an enzyme that diverts nicotinamide away from NAD+ production, converting it to 1-methylnicotinamide (1-MNA) which is then excreted. This process depletes the raw material needed for NAD+ synthesis. ❌ Without NNMT ProtectionNicotinamide → (NNMT converts) → 1-MNAExcreted in urine • Lost for NAD+ production → ✓ With NADShield ProtectionNicotinamide → (NAMPT converts) → NMN → NAD+Available for cellular energy • Salvage pathway preserved Key Insight: NNMT activity increases with aging, making NNMT inhibition increasingly important for older adults seeking NAD+ optimization. 📊 Research Background Multiple peer-reviewed studies confirm NNMT's role in NAD+ depletion. The enzyme converts nicotinamide (NAM) to 1-methylnicotinamide (1-MNA), effectively removing NAM from the NAD+ salvage pathway. This process uses SAM (S-adenosylmethionine) as a methyl donor, producing SAH (S-adenosyl-L-homocysteine), a precursor of homocysteine. Sources: Covarrubias et al., Nat Rev Mol Cell Biol. 2021 (PMID: 33353981) | Neelakantan et al., Biochem Pharmacol. 2018 | Kannt et al., Sci Rep. 2018 Standard NAD vs. Advanced NAD with NNMT Protection: Complete Comparison The difference between standard NAD supplements and Advanced NAD with NADShield comes down to one critical factor: NNMT protection. The table below illustrates how this protection changes the outcome of NAD supplementation. NAD Supplement Comparison: Protected vs. Unprotected Factor Standard NAD Supplements Advanced NAD + NADShield NNMT Protection ❌ None ✓ Vanillin-based inhibitor NAD Precursor Fate Degraded by NNMT → Excreted Protected → Available for NAD+ synthesis Salvage Pathway Depleted substrate pool Preserved substrate pool Absorption Speed 8+ hours typical 30 minutes Homocysteine Impact NNMT produces SAH → Hcy Reduced NNMT activity Sirtuin Compatibility Variable ✓ Includes resveratrol support Gut Support Usually none ✓ Includes probiotics Cellular Utilization Reduced by NNMT loss Maximized with protection Key Insight: The NNMT enzyme represents a "metabolic sink" that diverts NAD precursors away from productive use. By inhibiting NNMT activity with natural vanillin, Advanced NAD with NADShield ensures more of your supplement investment actually reaches its intended cellular targets. The Science of NNMT Inhibition: How Vanillin Protects Your NAD Vanillin (4-Hydroxy-3-methoxybenzaldehyde) is a natural compound found in vanilla beans that has been shown in peer-reviewed research to downregulate NNMT expression and activity. A 2021 study published in Oncology Reports demonstrated that vanillin: Decreased NNMT mRNA expression Reduced NNMT protein levels Lowered 1-MNA production (the product of NNMT activity) By reducing NNMT activity, more nicotinamide remains available for the NAD+ salvage pathway. This means more of your NAD precursor supplement can actually be converted to usable NAD+ rather than being methylated and excreted. Why NNMT Increases With Age Research shows NNMT expression increases in multiple tissues during aging, including adipose tissue, liver, and skeletal muscle. This age-related increase contributes to the well-documented decline in NAD+ levels that occurs with aging, making NNMT inhibition increasingly important for older adults. Mouse study showing improved endurance with NNMT inhibition over 8 weeks 📄 Key Study: Vanillin and NNMT "Vanillin was found to decrease NNMT expression and activity by reducing the 1-MNA level." Source: Liu Y et al. Oncol Rep. 2021 Jun;45(6):110. PMID: 33907844 NAD Supplement Comparison: How Advanced NAD Stacks Up in 2026 The NAD supplement market offers many options, but few address the NNMT degradation problem. Here's how Advanced NAD with NADShield compares to common alternatives: NAD Supplement Market Comparison (2026) Product Type NNMTProtection AbsorptionSpeed AdditionalSupport AddressesRoot Cause Advanced NAD + NADShield ✓ Yes 30 min Resveratrol + Probiotics ✓ Yes Standard NMN Capsules ❌ No Variable Usually none ❌ No Standard NR (Nicotinamide Riboside) ❌ No 1-2 hours Usually none ❌ No Nicotinamide (Vitamin B3) ❌ No Fast None ❌ No NAD+ IV Therapy ❌ No Immediate Varies ❌ No Note: NNMT protection addresses the root cause of inefficient NAD supplementation by preventing precursor degradation before cellular uptake. Research Evidence: NNMT Inhibition and Age-Related Benefits NNMT and the Aging NAD+ Decline NAD+ levels decline significantly with age, with some estimates suggesting a drop of 50% or more between ages 40 and 60. Multiple factors contribute to this decline, including increased consumption by repair enzymes (PARPs) and CD38, decreased production by NAMPT, and increased diversion by NNMT. Research published in Nature Reviews Molecular Cell Biology (2021) identified NNMT as a key regulator of NAD+ metabolism that becomes increasingly active with age, effectively creating a "metabolic sink" that diverts nicotinamide away from productive NAD+ synthesis. Benefits Observed in NNMT Inhibition Studies Animal studies with NNMT inhibitors have demonstrated: Improved muscle stem cell function in aged mice Enhanced endurance and physical performance Reduced body weight and improved insulin sensitivity Decreased adipocyte size and white adipose tissue mass Lower plasma cholesterol levels 📄 Key Study: Aged Muscle Regeneration "NNMT inhibitors constitute a viable pharmacological approach to enhance aged muscle regeneration by rescuing muscle stem cell function." Source: Swygert et al., Aging (Albany NY). 2019. PMC6469996 📄 Key Study: Metabolic Benefits "In vitro, NNMTi significantly decreased the intracellular production of MNAM, increased the intracellular levels of NAD+, and inhibited adipogenesis." Source: Front Pharmacol. 2024. PMC11196770 📄 Key Study: NNMT and Aging "NNMT activity increases over time, which is closely associated with the onset and progression of age-related diseases." Source: Metabolites. 2024. PMC11205546 Advanced NAD with NADShield: Complete Ingredient Profile NADShield Formula Components Each serving of Advanced NAD with NADShield delivers a comprehensive blend designed for maximum NAD optimization: Core NAD Protection: NAD Precursor (50mg): Rapid-absorption formula designed to reach cells in 30 minutes 4-Hydroxy-3-methoxybenzaldehyde (Vanillin): Natural NNMT inhibitor from vanilla beans, peer-reviewed for NNMT downregulation Synergistic Support: Trans-Resveratrol: Polyphenol antioxidant that supports sirtuin activation and works synergistically with NAD+ for longevity pathways Bifidobacterium Infantis: Beneficial probiotic enhancing gut health and nutrient absorption Lactobacillus Salivarius: Probiotic supporting balanced gut microbiome for optimal supplement utilization Why This Combination Works The NADShield formula addresses multiple aspects of NAD optimization simultaneously. While the NAD precursor provides raw material for cellular energy production, the vanillin-based NNMT inhibitor ensures these materials reach their targets intact. Resveratrol supports the sirtuins that depend on NAD+ for activity, while probiotics optimize gut health for enhanced absorption. NNMT Protection Natural vanillin inhibits NNMT activity, preventing premature breakdown of NAD precursors before cellular uptake. Rapid Delivery 30-minute absorption technology delivers NAD precursors to cells faster than traditional 8+ hour supplements. Sirtuin Support Trans-resveratrol activates sirtuins that require NAD+ for activity, creating synergistic longevity benefits. Gut Optimization Probiotics enhance gut health and nutrient absorption for maximum supplement utilization. Frequently Asked Questions About Advanced NAD with NADShield What is NNMT and why does it matter for NAD supplements? NNMT (Nicotinamide N-methyltransferase) is an enzyme that methylates nicotinamide (NAM), converting it to 1-methylnicotinamide which is then excreted. This diverts NAM away from the NAD+ salvage pathway, reducing the amount available for NAD+ synthesis. NNMT activity increases with aging, contributing to age-related NAD+ decline. How does vanillin inhibit NNMT? Vanillin (4-Hydroxy-3-methoxybenzaldehyde) has been shown in peer-reviewed research (PMID: 33907844) to downregulate NNMT expression and activity. It decreases NNMT mRNA and protein levels while reducing 1-MNA production, allowing more nicotinamide to remain available for NAD+ synthesis. Can I take this with other NAD supplements like NMN? Yes, Advanced NAD with NADShield complements other NAD supplements. The vanillin-based NNMT inhibitor operates independently to clear the metabolic pathway for all NAD precursors. Many users combine this with NMN for a multi-pathway approach to NAD optimization. How quickly does Advanced NAD absorb? Advanced NAD with NADShield features 30-minute absorption technology, delivering NAD precursors to cells much faster than traditional supplements that may take 8+ hours. Take with a full glass of water to activate rapid dissolution. Why is daily dosing required instead of pulse dosing? Unlike senolytics like fisetin that use pulse dosing, NADShield requires steady-state daily administration to keep NNMT enzyme levels consistently suppressed. NNMT is continuously active, so daily dosing maintains the protective effect against NAD precursor degradation. Does this supplement downregulate sirtuins? No, Advanced NAD with NADShield is formulated to work synergistically with sirtuins. The included trans-resveratrol actually supports sirtuin activation, and by protecting NAD precursors from NNMT degradation, the formula helps maintain the NAD+ levels sirtuins require. Scientific References Liu Y, et al. (2021). "Vanillin downregulates NNMT and attenuates NNMT-related resistance to 5-fluorouracil via ROS-induced cell apoptosis in colorectal cancer cells." Oncol Rep, 45(6):110. PMID: 33907844 Covarrubias AJ, et al. (2021). "NAD+ metabolism and its roles in cellular processes during ageing." Nat Rev Mol Cell Biol, 22(2):119-141. PMID: 33353981 Swygert KE, et al. (2019). "Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle." Aging (Albany NY), 11(4):1136-1154. PMC6469996 Gao Y, et al. (2021). "Nicotinamide N-methyl transferase (NNMT): An emerging therapeutic target." Drug Discov Today, 26(11):2699-2706. PMID: 34029690 Kannt A, et al. (2018). "A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders." Sci Rep, 8(1):3660. PMID: 29483591 Neelakantan H, et al. (2018). "Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase." J Med Chem, 60(12):5015-5028. PMID: 28525266 Imai S, Guarente L. (2016). "NAD+ and sirtuins in aging and disease." Trends Cell Biol, 24(8):464-471. PMID: 24786309 Note: All references are peer-reviewed studies available on PubMed. Research in NNMT inhibition and NAD metabolism continues to evolve. About This Article Written by Anthony Loera, Founder & CEO of RevGenetics, to provide evidence-based information about NNMT inhibition and NAD protection. All cited research is from peer-reviewed publications. Author: Anthony Loera | Publisher: RevGenetics Last Updated: January 7, 2026 FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Advanced NAD with NADShield is a dietary supplement intended for general health and wellness support only. Consult your healthcare provider before use. what is the best NAD supplement NAD supplement with NNMT inhibitor how to protect NAD from degradation vanillin NNMT inhibitor supplement NAD precursor protection best NAD supplement for anti-aging NADShield NNMT protection fast absorption NAD supplement NAD supplement with resveratrol NNMT enzyme inhibitor natural how to take NAD supplement NAD stacking protocol