Research grade Aflibercept biosimilar has the same amino acid sequence as Aflibercept (trade name Eylea), a recombinant protein composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors fused with the Fc region of human immunoglobulin gamma 1 (IgG1). It inhibits vascular endothelial growth factor (VEGF), and is used in the treatment of macular edema following Central Retinal Vein Occlusion (CRVO) and neovascular Age-Related Macular Degeneration (AMD). Aflibercept is a dimeric glycoprotein with a molecular weight of 96.9 kilo Daltons (kDa). Glycosylation adds its molecular weight to 115 kDa in total. Ziv-aflibercept (trade name Zaltrap) was developed as an injection for treatment of metastatic colorectal cancer. Aflibercept Biosimilar Recombinant protein composed of the binding domains of two human vascular endothelial growth factor (VEGF) receptors fused with the Fc region of human immunoglobulin gamma 1 (hIgG1).Source: The aflibercept biosimilar protein was produced in the Zaltrap / Eylea biosimilar CHO stable cell line.Specificity/Sensitivity: The aflibercept biosimilar protein specifically binds to the human VEGF.Applications: Functional assays, and those assays for studying biological pathways affected by aflibercept.Form of Protein: 0.2 uM filtered solution, pH 6.1, no stabilizers or preservatives.Endotoxin: 95% by SDS-PAGE under reducing conditions and HPLC.Shipping: The research grade aflibercept biosimilar protein is shipped with ice pack. Upon receipt, store it immediately at the temperature recommended below.Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70°C as supplied.1 month from date of receipt, 2 to 8°C as supplied.
