AFP Polyclonal Antibody SKU # E-AB-10000 Reactivity H Host Rabbit Applications WB, IHC, ELISA Test Application Verified Samples Reactivity Application Human WB (liver) Mouse IHC (kidney) Dilution: WB,,1:1000-1:5000;IHC,,1:50-1:200; Product Details Clonality Polyclonal Isotype IgG Concentration 0.5 mg/mL Storage Store at -20℃. Avoid freeze / thaw cycles. Buffer PBS with 0.05% sodium azide and 50% glycerol, PH7.4 Purification Method Affinity purification Research Areas Cancer, Cardiovascular, Developmental Biology Conjugation Unconjugated Immunogen Details Immunogen Recombinant protein of human AFP Abbre AFP Synonyms Afp,AFPD,Alpha fetoglobulin,Alpha fetoprotein,Alpha fetoprotein precursor,Alpha-1-fetoprotein,Alpha-fetoglobulin,Alpha-fetoprotein,alpha-fetoprotein,Hereditary persistence of,included,FETA,FETA,Hereditary persistence of alpha fetoprotein,HPAFP Swissprot P02771 Gene Accession BC027881 Calculated MW 69kDa Cellular Localization Secreted. Tissue Specificity Plasma. Synthesized by the fetal liver and yolk sac. Related Reagents Application Products WB Western Blot Detection Kit(E-IR-R304) IHC 2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution)(E-IR-R217) Background This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.
