The Skin Soother Every Formula Needs — Gentle, Proven, Versatile There are very few cosmetic actives that work across every skin type, every formula type, and every concern. Allantoin is one of them. Whether you’re formulating for sensitive skin, acne-prone skin, post-procedure recovery, or everyday hydration — allantoin belongs in your formula. It’s the quiet workhorse that makes everything feel better. Trusted by cosmetic chemists for decades, backed by extensive safety data, and loved by customers who don’t even know it’s there — because their skin just feels good. What Is Allantoin? For Beginners: Allantoin is a naturally occurring compound found in the comfrey plant (Symphytum officinale), as well as in wheat sprouts and sugar beets. In cosmetics, it’s used as a skin-soothing, healing, and softening active. It’s one of the safest and most well-studied ingredients in the industry — approved for use in over-the-counter skin protectant products by the FDA. For Experts: Allantoin (5-ureidohydantoin) is a diureide of glyoxylic acid. It functions as a keratolytic agent at higher concentrations, promoting desquamation and cell renewal, while at standard cosmetic usage rates (0.1–2%) it acts primarily as a skin protectant, anti-irritant, and moisturizing agent. It is amphoteric, non-ionic in behaviour at physiological pH, and compatible with a wide range of cosmetic systems. INCI: Allantoin What It Does For Skin ✦ Soothes irritation and redness — one of the most effective anti-irritant actives available; calms reactive, sensitive, and inflamed skin ✦ Accelerates skin healing — promotes cell proliferation and tissue repair; ideal for post-procedure, post-shave, and wound-adjacent formulas ✦ Softens and smooths — keratolytic action at higher concentrations helps loosen and remove dead skin cells for a smoother texture ✦ Boosts moisture retention — helps skin hold onto water, improving hydration and suppleness ✦ Reduces sensitivity to other actives — commonly used to buffer the irritation potential of retinoids, AHAs, BHAs, and vitamin C ✦ Safe for all skin types — including sensitive, acne-prone, eczema-prone, and post-procedure skin Formulation Details INCI Name Allantoin CAS Number 97-59-6 Appearance White crystalline powder Solubility Slightly soluble in cold water; more soluble in hot water (dissolves well at 70–80°C); slightly soluble in ethanol Recommended Usage 0.1 – 2% (standard cosmetic use); up to 2% for OTC skin protectant claims Incorporation Dissolve in hot water phase (70–80°C) before adding to formula; can also be pre-dispersed in glycerin pH Compatibility pH 3 – 8 (stable across a wide pH range) Ionic Character Non-ionic — compatible with anionic, cationic, and nonionic systems Shelf Life 3+ years when stored in a cool, dry place away from direct light Suitable For Moisturizers, serums, toners, cleansers, shaving products, after-sun, baby care, acne treatments, post-procedure formulas Formulator Tips ✔ Dissolve in hot water (70–80°C) for best results — allantoin has limited cold-water solubility and can leave undissolved particles if added to cool water ✔ Alternatively, pre-disperse in glycerin before adding to your water phase for easier incorporation ✔ Use at 0.2–0.5% for general soothing and anti-irritant benefits; increase to 1–2% for more pronounced healing and keratolytic effects ✔ Excellent as a buffer ingredient alongside retinoids, AHAs, BHAs, and vitamin C to reduce irritation potential without compromising efficacy ✔ Stable across a wide pH range — works in both acidic exfoliant formulas and alkaline cleansers ✔ Non-ionic and compatible with virtually all cosmetic systems — one of the easiest actives to formulate with ✔ Always include a broad-spectrum preservative in any water-containing formula Best Ingredient Pairings Allantoin is one of the most compatible actives in cosmetic formulation. It pairs beautifully with: D-Panthenol (Pro-Vitamin B5) — the ultimate skin-healing and soothing duo; synergistic barrier repair and moisture retention Hyaluronic Acid Powder LMW — layered hydration for serums and moisturizers Niacinamide Vitamin B3 — barrier support, brightening, and anti-inflammatory synergy Beta Glucan Powder — powerful soothing and barrier-repair combination for sensitive skin Malic Acid (AHA) — allantoin buffers AHA irritation while maintaining exfoliant efficacy Snail Mucin Powder — skin regeneration and healing synergy Ectoine Powder — extreme soothing and stress-protection for sensitive and reactive skin Germall Plus Preservative — broad-spectrum preservation for water-based formulas Geogard 221 Preservative — natural-origin preservation option Suggested Formulas All water-containing formulas must include a broad-spectrum preservative system appropriate for your formula’s pH and application. Always validate preservation efficacy with a Challenge Test before commercializing. Calming Sensitive Skin Serum Allantoin — 0.5% D-Panthenol (Pro-Vitamin B5) — 2% Hyaluronic Acid Powder LMW — 0.5% Niacinamide Vitamin B3 — 5% Beta Glucan Powder — 0.5% Glycerin — 5% Germall Plus or Geogard 221 — at supplier recommended usage rate Water — to 100% Post-Procedure Recovery Cream Allantoin — 1% D-Panthenol (Pro-Vitamin B5) — 3% Snail Mucin Powder — 2% Ectoine Powder — 1% Shea Butter — 5% Cetyl Alcohol — 3% Emulsifier (e.g. Olivem 1000 or BTMS-50) — 5% Germall Plus or Geogard 221 — at supplier recommended usage rate Water — to 100% 🪥 Soothing AHA Toner (with Irritation Buffer) Allantoin — 0.3% Malic Acid (AHA) — 5% (adjust pH to 3.5–4.0) Niacinamide Vitamin B3 — 3% Glycerin — 3% Germall Plus or Geogard 221 — at supplier recommended usage rate Water — to 100% Who Is This For? Allantoin Powder is ideal for formulators creating: Sensitive skin serums, moisturizers, and toners Post-procedure and wound-adjacent recovery products Acne treatments and blemish-calming formulas After-shave and after-wax products Baby care and eczema-prone skin formulas AHA/BHA exfoliant formulas (as an irritation buffer) After-sun and environmental stress recovery products Ready to Formulate? 🛒 Shop Allantoin Powder → Also explore our full catalogue of cosmetic actives — all sourced and stocked in Canada. Sold as a cosmetic raw material for professional formulation use. Not intended for direct skin application without a finished formula. Always conduct appropriate safety and stability testing, including preservative efficacy testing, before commercializing finished products.
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