Xanthine Oxidase Inhibitor Tablets to Prevent Urate Stones in Dogs Product Description Allopurinol 100mg Tablets are a prescription xanthine oxidase inhibitor used by veterinarians to manage elevated uric acid levels in adult dogs. It works by stopping the enzyme xanthine oxidase from turning purines into uric acid, which lowers the risk of urate crystals and stones forming in the bladder and kidneys. It is prescribed for dogs prone to recurrent urate urolithiasis, particularly those with portosystemic shunts or breed-specific metabolic tendencies, and is also used alongside other drugs in canine leishmaniasis management. Benefits Urate Urolithiasis Prevention: Brings urinary uric acid levels down to reduce the chance of urate crystals and bladder stones coming back in adult dogs. Breed-Specific Stone Management: Particularly helpful for Dalmatians and English Bulldogs, breeds that are genetically wired to produce higher uric acid and develop urate stones. Leishmaniasis Combination Therapy: Given alongside antiprotozoal drugs as a long-term part of canine leishmaniasis treatment plans. Chemotherapy Uric Acid Support: Keeps uric acid from rising dangerously in dogs going through cancer chemotherapy where tumor lysis is a concern. Lower Dose Flexibility: The 100mg size gives more room for precise low-end dosing in smaller dogs or those starting on a more conservative amount. Ingredients Active Ingredients Allopurinol How to Use Allopurinol 100mg Tablets are a prescription-only medication. A valid veterinarian prescription is required to purchase this product. Please follow your veterinarian's specific instructions for the dosage and administration of this medication for your pet. Disclaimer: Dosage and administration of this medication must be determined by a licensed veterinarian. Always consult your veterinarian before administering or adjusting any prescription medication for your pet. Giving this tablet with a meal helps keep stomach discomfort from coming up, and making sure your dog has fresh water available throughout the day is an important part of the routine. Tucking the tablet into a soft pill pocket or pill wrap treat alongside the meal is a simple way to get your dog to take their full dose without any trouble. Shop Pill Pockets for Dogs Additional Information Precautions Adult Dogs Only: This medication is formulated for adult dogs only and should never be given to puppies, kittens, or cats. Long-Term Xanthine Stone Risk: Xanthine uroliths can develop in the bladder or kidneys over time, making routine urinalysis an important part of ongoing care. Caution in Organ Disease: Reduced liver or kidney function can slow how this medication clears from the body, putting dogs at greater risk of adverse effects. Avoid in Pregnancy: How this medication affects breeding, pregnant, or nursing animals is not established, so direct veterinary oversight is needed before use. Known Allergy Caution: Dogs with a known sensitivity or prior allergic reaction to allopurinol should not be given this medication. Drug Interaction Risk: Share a full list of your dog's current medications, including azathioprine, mercaptopurine, warfarin, furosemide, and ammonium chloride, with your veterinarian before starting. Give With Food and Water: Pairing each dose with food helps reduce gastrointestinal effects, and keeping fresh water available all day is essential throughout treatment. Possible Side Effects Drowsiness: Some dogs on allopurinol experience mild sedation and tiredness, most noticeably in the earlier stages of treatment. Nausea and Vomiting: Stomach upset, including vomiting and diarrhea, tends to come up more when the tablet is given on an empty stomach. Skin and Eye Irritation: Rashes and eye irritation have been noted in some dogs on this medication and should be flagged to a veterinarian promptly. Xanthine Stone Formation: Long-term use can cause xanthine crystals to build up in the urinary tract, which needs ongoing veterinary monitoring and management. Serious Allergic Reactions: Hives, swelling, trouble breathing, bloody urine, or painful urination all point to a serious reaction that needs immediate emergency veterinary care. Storage Information Room Temperature: Tablets do best at room temperature inside a securely closed container, kept away from heat and humidity. Protect From Light and Moisture: Direct sunlight and damp areas can wear down the tablet's potency, so a dry, shaded storage spot is the right choice. Out of Reach: Keep this medication somewhere children and untreated animals in the home cannot get to it. NOTE: For generic medications, the product image shown may not reflect the actual item received. Generic medications can vary in size, color, and shape between orders depending on the manufacturer. Additionally, your medication may arrive packaged in a HardyPaw Pharmacy vial. Shipping & Return We offer ground, express, and priority delivery; see our shipping policy for details. For return instructions or product concerns, please refer to our detailed refund policy. Prescription items are NON-RETURNABLE and NON-REFUNDABLE. Frequently Asked Questions Q1: Which dog breeds are most commonly prescribed allopurinol and why? Ans: Dalmatians and English Bulldogs are the breeds most often prescribed allopurinol because a genetic difference in how they process uric acid makes them particularly prone to urate stone formation. Dogs with portosystemic shunts also fall into this high-risk group. A veterinarian will confirm whether allopurinol is the right long-term option for a specific dog. Q2: Can allopurinol dissolve existing urate stones in dogs? Ans: Allopurinol lowers uric acid production to stop new urate stones from forming, but it does not break down stones that are already there. It is usually combined with a low-purine prescription diet to work on both fronts. A veterinarian will put together the most suitable plan based on the dog's current situation. Q3: How long does a dog need to stay on allopurinol treatment? Ans: How long treatment continues depends on what is driving the problem. Dogs with genetic uric acid issues or leishmaniasis may need to stay on it long-term or indefinitely. A veterinarian will review how the dog is doing through regular urine and blood tests and adjust the plan from there. Q4: How does allopurinol help dogs being treated for leishmaniasis? Ans: In leishmaniasis management, allopurinol is used long-term alongside antiprotozoal drugs like meglumine antimoniate or miltefosine. It works by getting in the way of the parasite's RNA production, which brings the parasite load down and helps keep the disease in remission over an extended period. Q5: What monitoring does a dog on allopurinol require during treatment? Ans: Routine urinalysis to check for xanthine crystals or stones and regular bloodwork to keep an eye on kidney and liver function are both part of staying on top of things during treatment. Dogs being treated for leishmaniasis also need periodic parasite load checks. A veterinarian will work out the right monitoring schedule based on the dog's condition and how long treatment has been running.
