Alpha-Arbutin Powder — Gentle, High-Efficacy Skin-Brightening Active What it is: Alpha-Arbutin is a biosynthetic glycoside of hydroquinone — one of the most clinically validated brightening actives in cosmetic science. It works by reversibly inhibiting tyrosinase, the key enzyme in melanin synthesis, to visibly reduce dark spots, hyperpigmentation, and uneven skin tone without the irritation associated with hydroquinone or high-dose vitamin C. Who it's for: Ideal for beginners formulating their first brightening serum and for advanced formulators building targeted hyperpigmentation, melasma, or post-inflammatory pigmentation (PIH) treatments. Alpha-Arbutin is one of the safest and most effective brightening actives available — suitable for all skin types including sensitive. Professional cosmetic ingredient — not a finished product. Formulation Specs INCI Name Alpha-Arbutin CAS No. 84380-01-8 Appearance White to off-white crystalline powder Purity ≥99% Solubility Freely water-soluble; dissolves readily at room temperature pH Compatibility Stable across pH 4.0–7.0; optimal at pH 5.0–6.5 Typical Usage Rate 0.5–2% (2% is the most studied efficacious dose) Incorporation Phase Water phase (Phase A); heat-stable up to 80°C Preservative Compatibility Compatible with all standard preservative systems Why Formulators Choose Alpha-Arbutin Targeted tyrosinase inhibition — reversibly blocks the enzyme responsible for melanin production, reducing pigmentation at the source without cytotoxicity Clinically validated brightening — shown to reduce melanin index and improve skin luminosity in peer-reviewed studies at 1–2% Gentle & well-tolerated — no irritation, sensitization, or photosensitivity risk; safe for daily use and all skin tones Stable in formulation — the alpha configuration is significantly more stable and more potent than beta-arbutin Broad compatibility — pairs synergistically with Niacinamide, Tranexamic Acid, Vitamin C derivatives, and AHAs for stacked brightening Suitable for all skin types — including sensitive, reactive, and melanin-rich skin tones where harsher actives are contraindicated How to Incorporate Weigh Alpha-Arbutin powder into your water phase (Phase A) — it dissolves readily at room temperature with gentle stirring It is heat-stable up to 80°C and can be added during hot-process emulsification Adjust the pH of your finished formula to 5.0–6.5 for optimal stability and efficacy Add your preservative system at cool-down as normal — Alpha-Arbutin does not interfere with preservative efficacy For maximum brightening impact, combine with Niacinamide or Tranexamic Acid to target multiple melanin pathways simultaneously Recommended Pairings Alpha-Arbutin shines brightest when combined with complementary brightening and barrier actives: Niacinamide B3 — dual-pathway brightening; inhibits melanosome transfer while Alpha-Arbutin blocks tyrosinase — a gold-standard duo Tranexamic Acid — targets melasma and PIH via plasmin inhibition; stacks powerfully with Alpha-Arbutin 3-O-Ethyl Ascorbic Acid (Stable Vitamin C) — antioxidant brightening that complements tyrosinase inhibition Hyaluronic Acid HMW — hydration base for a complete brightening serum Ectoine — barrier support and calming; ideal for sensitive skin brightening formulas Allantoin — soothing and skin-smoothing; great for post-inflammatory pigmentation formulas Suggested Formula: 2% Alpha-Arbutin Brightening Serum A lightweight, targeted brightening serum for dark spots, hyperpigmentation, and uneven skin tone. Suitable for all skin types. Ingredient % Phase Distilled Water (Aqua) to 100% A Alpha-Arbutin Powder 2.0% A Niacinamide B3 5.0% A Hyaluronic Acid HMW 0.1% A Ectoine 1.0% A Allantoin 0.5% A Glycerin 3.0% A Broad-spectrum preservative (e.g. Geogard ECT, Naticide) per supplier spec C (cool-down) Citric Acid / Sodium Hydroxide q.s. C Target pH: 5.5–6.0 | Viscosity: Low (serum) | Shelf life: 12 months with appropriate preservative Storage & Safety Store tightly sealed in a cool, dry place away from direct light and heat. Keep out of reach of children. For external use in finished cosmetic formulations only. Always conduct stability and challenge testing on your finished product before launch.
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