NeuroScience Alpha GABA Ingredients to promote calm during times of anxiousness while supporting a healthy response to stress, day or night. Patient Profile: Need to "downshift" from feeling mentally engaged Feelings of anxiousness, seeking to restore relaxation and calm Desire for help balancing stress The Science: GABA is the primary inhibitory neurotransmitter in the brain GABA is important for calmness and sleep Glutamate is the primary excitatory neurotransmitter in the brain Glutamatergic signaling underlies mechanisms related to anxiousness and stress For more information, check out our blog post - NeuroScience - It’ll Blow Your Mind! Ingredients Serving Size: 3 Capsules Amount/Serving Vitamin B6 (as pyridoxal 5'-phosphate) 2 mg L-theanine 400 mg Ashwagandha extract (Withania somnifera) (root and leaf) 250 mg Proprietary Blend: 620 mg Passion flower extract (Passiflora incarnata) (aerial parts), Lemon balm extract (Melissa officinalis) (aerial parts), and L-taurine Other Ingredients: Vegetable capsule (hypromellose, water), microcrystalline cellulose, organic rice concentrate, and silica. Suggested Use Take 2-3 capsules up to two times daily or as directed by your healthcare provider. Do not exceed the suggested use. Warning: If you are pregnant or nursing, consult your healthcare provider before use. Keep out of children. Storage: This product has a tamper-evident seal under the cap. Do not use if the seal is broken or missing. Store at room temperature, in a dry place. More Info. Stress processing and the symptom cycle Stress, GABA, and the HPA axis GABA signaling inhibits corticotropin-releasing hormone (CRH) and glutamate signaling stimulates CRH Stress increases CRH secretion, stimulating the hypothalamic pituitary adrenal (HPA) axis and adrenal gland production of cortisol and the catecholamines Chronic stress causes neuroplastic changes in the paraventricular nucleus, decreasing GABA receptor expression and increasing glutamate receptor expression, perpetuating the stress response Alpha GABA provides a multi-faceted approach to stress management with ingredients to reduce symptoms of anxiousness while supporting a healthy stress response. Complete stress support Alpha GABA contains ingredients to: Induce relaxing alpha brain waves and feelings of calm with a targeted neurotransmitter approach Provide comprehensive HPA axis support for optimal stress management Support the circadian rhythm for patients already feeling the "fight or flight" response by adding Calm CP or Calm PRT