Tricyclic Antidepressant Tablets for Anxiety and Pain in Pets Product Description Amitriptyline 100mg Tablets are a prescription tricyclic antidepressant used by veterinarians for dogs and cats. It works by slowing the brain's uptake of serotonin and norepinephrine, which helps settle mood, ease anxiety, and quiet chronic pain signals. It is commonly used for separation anxiety, noise phobias, compulsive behaviors in dogs, inappropriate urination and spraying in cats, and neuropathic pain management in both species. Benefits Anxiety and Fear Relief: Addresses separation anxiety, noise phobias, and fear-based behavioral disorders in both dogs and cats. Compulsive Behavior Support: Helps bring compulsive behaviors like excessive licking, tail chasing, and repetitive grooming under better control in pets. Cat Elimination Issues: Reduces inappropriate urination outside the litter box, spraying, and anxiety-driven elimination behaviors in cats. Neuropathic Pain Relief: Used to relieve chronic nerve pain tied to osteoarthritis, intervertebral disc disease, and other neuropathic conditions. Anti-Itch Properties: Carries secondary antihistamine effects that help ease itching and skin irritation in dogs with pruritic conditions. Ingredients Active Ingredients Amitriptyline Hydrochloride How to Use Amitriptyline 100mg Tablets are a prescription-only medication. A valid veterinarian's prescription is required to purchase this product. Please follow your veterinarian's specific instructions for the dosage and administration of this medication for your pet. Disclaimer: Dosage and administration of this medication must be determined by a licensed veterinarian. Always consult your veterinarian before administering or adjusting any prescription medication for your pet. Placing this tablet inside a soft pill pocket or pill wrap treat is a simple way to get your pet to take their dose without any fuss. Keeping fresh water available for your pet throughout the treatment period is also a good habit to maintain. Shop Pill Pockets for Dogs | Shop Pill Pockets for Cats Additional Information Precautions Avoid With MAOIs: Pets that have had a monoamine oxidase inhibitor like selegiline or amitraz in the past 14 days should not receive this medication. Never Stop Abruptly: Stopping this medication without a gradual taper can bring on withdrawal symptoms like nausea and general discomfort in pets. Avoid in Hyperthyroidism: Pets with a confirmed hyperthyroidism diagnosis should not be given this medication due to toxic thyroid hormone interactions. Caution in Heart Conditions: Pets with cardiac arrhythmias need extra care, as this medication can interfere with heart rhythm and electrical conduction. Caution in Glaucoma and Urinary Retention: Best avoided in pets with glaucoma or a history of urinary retention, as both conditions may worsen. Avoid Flea Collars: Amitraz-containing flea collars should not be used alongside this medication due to a serious MAOI interaction risk. Serotonin Syndrome Risk: Pairing this medication with SSRIs, trazodone, or tramadol raises the risk of serotonin syndrome, which can be life-threatening in rare cases. Possible Side Effects Sedation and Drowsiness: Sleepiness tends to be the most noticeable early reaction and often settles down as the pet gets used to the medication. Urinary Retention: Trouble urinating or a drop in urinary output are worth flagging to a veterinarian if they come up during treatment. Digestive Upset: Constipation, vomiting, diarrhea, and a reduced appetite are digestive reactions some pets may go through on this medication. Heart Rhythm Changes: Cardiac arrhythmias are an uncommon but serious concern that needs veterinary monitoring throughout any long-term use. Blood Count Changes: Platelet or white blood cell levels can dip in some pets, so routine bloodwork checks are a good idea during treatment. Storage Information Room Temperature: Tablets do best at room temperature inside a tightly closed container, kept away from excess heat and humidity. Protect From Sunlight: Direct sunlight can break down the medication over time, so a dry, shaded storage spot is the way to go. Out of Reach: Keep this medication somewhere children and untreated animals in the home cannot get to it. NOTE: For generic medications, the product image shown may not reflect the actual item received. Generic medications can vary in size, color, and shape between orders depending on the manufacturer. Additionally, your medication may arrive packaged in a HardyPaw Pharmacy vial. Shipping & Return We offer ground, express, and priority delivery; see our shipping policy for details. For return instructions or product concerns, please refer to our detailed refund policy. Prescription items are NON-RETURNABLE and NON-REFUNDABLE. Frequently Asked Questions Q1: What is amitriptyline used for in dogs and cats? Ans: Amitriptyline is used for separation anxiety, noise phobias, compulsive behaviors, neuropathic pain, and inappropriate elimination in cats. By slowing the brain's uptake of serotonin and norepinephrine, it helps settle mood, ease anxiety-driven behaviors, and quiet chronic pain signals in pets. Q2: How long does amitriptyline take to work in dogs and cats? Ans: Amitriptyline may take several days to a few weeks before the full behavioral or pain-relieving effects become noticeable. Most pets start showing some improvement after a few days of consistent dosing. A veterinarian will keep an eye on the response and fine-tune the dose if needed. Q3: Can amitriptyline be stopped suddenly in pets? Ans: No, stopping this medication without tapering it down can bring on withdrawal symptoms like nausea, discomfort, and behavioral changes. Always check in with your veterinarian before cutting back or stopping the dose, since a gradual reduction is usually the safer way to go. Q4: What medications should not be given with amitriptyline in pets? Ans: Monoamine oxidase inhibitors, amitraz-containing flea collars, and SSRIs like fluoxetine should not be used alongside amitriptyline, as the combination can set off serotonin syndrome. Tramadol, trazodone, and anticholinergic medications also call for extra caution. Always give your veterinarian a full list of current medications. Q5: What are the most common side effects of amitriptyline in dogs and cats? Ans: Sedation, reduced appetite, constipation, and urinary retention are what pets most often experience on this medication. Heart rhythm changes and lower platelet counts are less common but worth watching for. Pets on long-term treatment benefit from routine bloodwork and heart monitoring by a veterinarian.
