Supports Cognitive Function and PDH in Dogs Product Description Anipryl is a prescription tablet for dogs that is given by mouth to help manage signs of canine cognitive dysfunction and uncomplicated pituitary dependent hyperadrenocorticism. It contains selegiline hydrochloride, which works by increasing dopamine levels in the brain to support normal brain function and behavior. Given once a day, it comes in flexible dose strengths and has been clinically shown to improve both cognitive symptoms and signs related to PDH. Benefits Cognitive Support: Helps control disorientation, altered sleep cycles, and loss of housetraining in aging dogs. PDH Symptom Control: Assists in managing clinical signs of uncomplicated pituitary-dependent hyperadrenocorticism in dogs. Dopamine Enhancement: Selectively inhibits MAO B to increase dopamine levels in the central nervous system. Once Daily Dosing: Administered once daily, preferably in the morning, for convenient long-term management. Flexible Strength Options: Available in multiple tablet strengths to allow individualized dosing based on body weight. Variants 10 mg Tablets15 mg Tablets30 mg Tablets Ingredients Composition Table Ingredient Quantity Selegiline Hydrochloride 2 mg Selegiline Hydrochloride 5 mg Selegiline Hydrochloride 10 mg Selegiline Hydrochloride 15 mg Selegiline Hydrochloride 30 mg How to Use Recommended-Dosage Chart Indication Recommended Dosage Frequency Notes Canine Cognitive Dysfunction Syndrome 0.5 to 1.0 mg per kg body weight Once daily Preferably administered in the morning. Pituitary Dependent Hyperadrenocorticism 1.0 mg per kg body weight Once daily May increase to maximum 2.0 mg per kg if no improvement after 2 months. Dosage & Administration Instructions Prescription Required: This medication is restricted to use by or on the order of a licensed veterinarian. Morning Administration: Administer once daily, preferably in the morning, to support recommended therapeutic use. Dose Adjustment: Adjust dosage based on individual response and tolerance, under veterinary supervision. PDH Reassessment: If no improvement after dose increase, reevaluate and consider alternative therapy. Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet. Additional Information Precautions Behavioral Use Limitation: Not recommended for the treatment of other behavior problems, such as aggression. Drug Interactions: Avoid concurrent use with SSRIs, tricyclic antidepressants, or other antidepressants. Fluoxetine Washout: Allow at least five weeks after discontinuing fluoxetine before starting Anipryl. PDH Confirmation: Confirm pituitary-dependent hyperadrenocorticism diagnosis before initiating therapy for that condition. Breeding Safety: Safety has not been determined in breeding, pregnant, or lactating dogs. Possible Side Effects Gastrointestinal Signs: Vomiting and diarrhea were commonly reported during clinical field trials. Restlessness Behavior: Hyperactivity, irritability, and restlessness were observed in treated dogs. Appetite Changes: Anorexia and weight loss have been reported in some dogs. Neurologic Effects: Ataxia, disorientation, incoordination, and seizure-like activity were reported. Lethargy Weakness: Lethargy and generalized weakness occurred in some treated dogs. Storage Information Room Temperature: Store at controlled room temperature between 20° to 25° Celsius. Original Packaging: Keep tablets in original blister packaging until administration. Child Safety: Keep out of reach of children and not for human use. Shipping & Return We offer ground, express, priority, and international delivery; see our shipping policy for details. For return instructions or product concerns, please refer to our detailed refund policy. Prescription items are NON-RETURNABLE and NON-REFUNDABLE. Frequently Asked Questions Q1: What is Anipryl used for in dogs? Ans: Anipryl is prescribed to manage the symptoms linked to canine cognitive dysfunction and uncomplicated pituitary dependent hyperadrenocorticism. It increases dopamine activity in the brain, which can help reduce behavior changes and hormone related issues seen in affected dogs. Q2: How long does Anipryl take to show results? Ans: In clinical trials for cognitive dysfunction, improvement was observed after four weeks of treatment, with some dogs continuing to improve up to three months. For pituitary-dependent hyperadrenocorticism, many responding dogs showed improvement within one to two months of therapy initiation. Q3: What is the recommended dosage of Anipryl for dogs? Ans: For canine cognitive dysfunction, the recommended dosage is 0.5 to 1.0 mg per kg once daily. For pituitary-dependent hyperadrenocorticism, the recommended dosage is 1.0 mg per kg once daily, which may be increased to 2.0 mg per kg if needed. Q4: Can Anipryl be given with other antidepressant medications? Ans: Anipryl should not be used together with selective serotonin reuptake inhibitors, tricyclic antidepressants, or other antidepressant medications. After stopping Anipryl, wait at least 14 days before starting any of these drugs. If fluoxetine has been used, a longer waiting period of five weeks is required before beginning Anipryl. Q5: What are the common side effects of Anipryl in dogs? Ans: In clinical trials, the most commonly reported side effects included vomiting, diarrhea, increased activity, loss of appetite, tiredness, and nervous system changes such as unsteady movement or confusion. Most of these reactions were mild, but a small number of dogs needed a dose adjustment or had to stop the medication.
