Designs For Health Annatto-E™ 150 Targeted Metabolic and Antioxidant Support Promotes optimal vitamin E status with the preferred form of vitamin E as tocotrienols. May support cardiovascular, skin, eye, bone, and lung health and antioxidant status. Our formula contains the two most bioactive forms of vitamin E tocotrienols (gamma and delta), shown to provide superior support for cardiovascular, liver, and cellular health compared to other vitamin E compounds. Most conventional supplements are typically rich in tocopherols (alpha‑tocopherol, in particular). However, the tocotrienol forms of vitamin E have beneficial effects across various body systems that allow them to uniquely support overall wellness. Owing to these benefits, Annatto‑E® may be clinically relevant to the general population. Key Features and Benefits: Supports vitamin E status Promotes metabolic and cardiovascular health Supports antioxidant status and a healthy inflammatory response Supports lung, skin, and eye health Supports healthy bones Ingredients Serving Size: 1 Softgel Amount/Serving Vitamin E Isomers (as DeltaGold® [as delta- and gamma-tocotrienols from annatto (Bixa orellana)(seed)] 150 mg Other Ingredients: Bovine gelatin, glycerine, medium chain triglycerides, water. Gluten-Free, Dairy Free, Soy Free, Non-GMO Suggested Use Take 1 softgel per day or as directed by your health-care practitioner. Warning: Keep out of reach of children. Storage: Keep lid tightly closed. Store in a cool, dry place, away from direct light. More Info. Annatto-E® delivers pure delta- and gamma-tocotrienols sourced from annatto (Bixa orellana), the richest known source of naturally occurring tocotrienols. Vitamin E consists of eight forms within two categories — tocotrienols and tocopherols — each with unique properties that influence function and effects on the body. Most conventional vitamin E supplements are rich in tocopherols (alpha-tocopherol in particular), yet the tocotrienol forms have unique effects across various body systems that make them desirable for supporting many aspects of health and overall wellness. Annatto-E® is made with DeltaGold®, containing 100% tocotrienols and 0% tocopherols. Available in two serving size options — 150 mg and 300 mg — to support flexible clinical dosing. Because tocopherols may potentially interfere with the clinical benefits of tocotrienols, it may be best to take Annatto-E® independently of any other supplement containing alpha-tocopherols, or to separate intake by at least 6 hours. Antioxidant and Inflammatory Response Support Tocotrienols support antioxidant status through potent free radical scavenging activity. Their unique molecular structure — featuring a shorter, unsaturated side chain compared to tocopherols — allows tocotrienols to distribute more efficiently in cell membranes. This antioxidant activity also supports a healthy inflammatory response throughout the body. Cardiovascular and Metabolic Health Delta- and gamma-tocotrienols promote metabolic and cardiovascular health. The tocotrienol forms of vitamin E have demonstrated unique effects on cardiovascular markers and metabolic function, supporting healthy aging and overall metabolic wellness. Multi-System Support The tocotrienols in Annatto-E® may support cardiovascular, skin, eye, bone, and lung health. This broad-spectrum activity across multiple body systems makes tocotrienol supplementation clinically relevant for the general population seeking comprehensive vitamin E support.