Apagard Premio— Whitening and strengthening paste with high content of medical nano-hydroxyapatite (nano-mHAP), 100 g

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Apagard Premio — The Top of Sangi's Hydroxyapatite Range, 100 g Overview Sangi is the company that licensed NASA's hydroxyapatite work in the 1970s and turned it into a toothpaste active, and Premio is the version with the most of it. Where a conventional whitening paste relies on abrasive particles to scrub stain off, Apagard's approach is to supply the mineral the enamel is made of: medical hydroxyapatite adsorbs plaque, lifts it away, and fills the microscopic surface defects that make an enamel surface look dull and hold stain in the first place. Two things about this tube are worth knowing before you buy, and neither is on the front of the box. It contains no fluoride at all — that is a design decision, not an oversight, and it matters if fluoride is part of your decay prevention. And its lustre agent is hydrolysed conchiolin, a protein from pearl and mollusc shell, which makes it unsuitable for anyone with a shellfish allergy. Browse the whole Japanese oral care range, or the wider selection of Japanese health products we ship from Kobe. Key Benefits The highest medical hydroxyapatite content in the Apagard range Works by supplying enamel mineral rather than by abrasion, so it is gentle on exposed root surfaces Macrogol 400 targets protein-bound deposits that plain abrasives leave behind β-glycyrrhetinic acid and cetylpyridinium chloride address the gum margin and breath Xylitol and a light mint flavour rather than the sharper peppermint of M-Plus and Smokin' Full ingredient list published here, including the mollusc-derived lustre agent Product Details Brand Apagard / Sangi (サンギ) Country of origin Japan Product type Toothpaste (dentifrice) Regulatory class (Japan) Quasi-drug (医薬部外品) — a Japanese category between cosmetic and medicine, requiring approval of the active ingredient Net weight 100 g Flavour Light mint Key active Medical hydroxyapatite (mHAP) — highest content in the Apagard range Fluoride None — fluoride-free by design Format Squeeze tube in a printed Japanese carton JAN code Printed on the Japanese carton. We have not verified a JAN for this pack size against the manufacturer's published data, so we do not state one here — ask us and we will photograph the barcode on the stock we hold. Sold by Tsujimoto Market, Kobe, Japan Who Is This For? People who want a fluoride-free paste with a mineral active rather than no active at all Anyone whose main concern is surface stain from coffee, tea or red wine Adults who alternate a hydroxyapatite paste with a fluoride paste rather than choosing one Anyone who prefers a low-abrasion paste over a whitening paste that works by scrubbing Not for you if you have a mollusc or shellfish allergy, or if you need fluoride protection — especially for a child with a history of cavities How to Use Wet the brush lightly or use it dry — Apagard is a low-abrasion paste and does not need much water. Squeeze out a brush-length of paste, around one gram for an adult brush. Brush for two minutes, covering the gum margin as well as the tooth surfaces. Spit out the paste. Rinse once with a small amount of water rather than several mouthfuls, so the hydroxyapatite stays in contact with the enamel a little longer. Rinse the brush and stand it head-up to dry. Frequency: Twice a day, morning and night, as part of ordinary brushing. Full Ingredients Approved active ingredients Medical hydroxyapatite (mHAP) — Sangi's approved active; adsorbs and removes plaque and remineralises microscopic enamel defects Macrogol 400 — dissolves protein-bound deposits on the enamel surface β-glycyrrhetinic acid — anti-inflammatory, for the gum margin Cetylpyridinium chloride — bactericidal, works against the bacteria involved in bad breath Full ingredients (as published by the manufacturer) Base: dibasic calcium phosphate (dental grade), anhydrous silicic acid. Solvent: purified water. Humectant: concentrated glycerin, sodium silicate. Sweetener: xylitol, sodium saccharin. Medicinal components: medical hydroxyapatite, macrogol 400, β-glycyrrhetinic acid, cetylpyridinium chloride. Foaming agent: sodium lauryl sulfate. Binder: sodium carboxymethylcellulose. Flavouring: fragrance. Stabiliser: magnesium phosphate. Lustre agent: hydrolysed conchiolin solution. Preservative: alkyldiaminoethylglycine hydrochloride. Ingredient list as declared by the manufacturer. Formulations are occasionally revised, so always read the list printed on the package you receive. Cautions Contains hydrolysed conchiolin solution, a protein extracted from pearl and mollusc shell, used here as a lustre agent. If you have a shellfish or mollusc allergy, do not use this paste. Sangi does not publish the mollusc species used. Contains no fluoride. Apagard is built around medical hydroxyapatite instead, which is a deliberate design choice, not an omission. If you or your dentist rely on fluoride for decay prevention — particularly for a child, or if you have a history of cavities — this paste does not provide it, and many people therefore alternate it with a fluoride paste rather than replacing one with the other. For adults and children who can reliably spit out. Do not swallow. Rinse after brushing. Stop using the paste and consult a dentist if the gums, mouth or lips become sore, red or swollen, or if a rash appears. This is a toothpaste, not a treatment for gum disease, decay or sensitivity. If you have bleeding gums, a persistent ache or a tooth that reacts to cold, see a dentist rather than changing paste. Do not use as a substitute for professional cleaning or for a filling that needs replacing. Keep out of reach of small children. Store away from direct sunlight and high temperatures. Package Contents One 100 g tube of toothpaste in its Japanese retail carton. Nothing is decanted or repackaged. Shipping & Store Notes Ships directly from Japan Processing time: 2–6 business days Tracking number provided after dispatch Import duties and taxes may apply depending on destination country Opened cosmetics cannot be returned for hygiene and safety reasons Authenticity Guarantee Every product at Tsujimoto Market is sourced directly from Japan and verified for authenticity. We never sell fakes or grey-market goods. Each order is carefully packed in Kobe, Japan and dispatched with full tracking. FAQ How do Premio, M-Plus and Smokin' differ? They share the same four medicinal components and the same base. Premio carries the highest medical hydroxyapatite content of the three and adds xylitol and sodium silicate, with a light mint flavour. M-Plus is the standard formulation in peppermint. Smokin' is M-Plus plus polyvinylpyrrolidone, a second agent aimed at tar deposits from tobacco, also in peppermint. If you do not smoke and are not chasing the highest mHAP level, M-Plus is the sensible default. What does hydroxyapatite actually do in a toothpaste? Hydroxyapatite is the mineral tooth enamel is largely made of, so a paste containing it is supplying the same material the enamel surface is built from. Sangi's approved Japanese claims for medical hydroxyapatite are that it adsorbs and removes plaque and remineralises microscopic enamel defects. Those are the claims the quasi-drug approval covers; anything beyond them — whitening a stained tooth back to its original shade, repairing a cavity — it does not cover, and neither do we. Will it whiten my teeth? It will remove surface stain, and that is what the Japanese "whitening" wording on the tube means — 歯を白くする, literally "makes teeth white", is an approved cleaning claim about removing what sits on the enamel. It does not bleach. If your teeth are darker than you would like because of the natural colour of the dentine underneath rather than coffee and tea on the surface, no toothpaste sold in Japan or anywhere else will change that; peroxide bleaching at a dental clinic will. Is this product halal or suitable for vegans? This paste contains hydrolysed conchiolin — protein from pearl and mollusc shell — so it is not vegan. For halal purposes, marine molluscs are treated differently by different schools of jurisprudence, and Sangi neither publishes the species nor certifies the product as halal, so the correct description is unverified rather than permitted or forbidden. The remaining ingredients are mineral or synthetic; there is no alcohol and no gelatin. If certification matters to you, this product does not have it. Does it contain SLS? Yes — sodium lauryl sulfate is the foaming agent. It is the ingredient most often blamed for recurrent mouth ulcers, and people prone to aphthous ulcers sometimes find they get fewer of them on an SLS-free paste. If that is you, this is not the tube to buy. For everyone else SLS is simply what makes the paste foam. Show more