White Spot Cure from the API aquarium treatment range eliminates white spot quickly and effectively in both tropical and coldwater fish. API White Spot Cure also provides a slime coating for added protection. Ich, a protozoan parasite, also known as white spot disease, is caused by the external parasite Ichthyophthirius multifiliis. This microscopic parasite has a multi-staged life cycle and is invisible during its theront stage. Theronts burrow into gill and skin tissue causing severe electrolyte loss and gill damage, this can result in secondary bacterial and/or fungal infections. Early symptoms of this infection can include fish darting around the aquarium and scratching against the gravel and ornaments. Fish also exhibit labored breathing and may remain at the water’s surface, near filters and aeration devices. White spots may or may not be visible on fish. API White Spot Cure kills the Ich parasite, usually within 24 hours and is safe for use in both freshwater and saltwater aquariums. Directions:Remove activated filter carbon from filter and continue aeration. Add 5ml per 20 litres of aquarium water. Repeat dose after 48 hours. Wait another 48 hours then change 25% of the aquarium water and add fresh activated carbon. Treatment may be hastened by raising the temperature to 28°C. Dosage Rate:- 118ml treats up to 447 Litres Please Note:Some scaleless fish are sensitive to this medication; therefore, treat at ½ the normal dose. Some saltwater invertebrates, such as corals, may be sensitive to this product, so it is not recommended for reef aquariums.