A daily adaptogen formulation designed to support stress modulation, mood stability, and sleep quality during menopause and perimenopause. Combines clinically studied Ashwagandha with black pepper to optimize bioavailability. All batch testing and Certificates of Analysis are available in the Menopause Science Trust Center. Clinical Profile Targets Stress response and cortisol regulation Mood variability Sleep latency and continuity Nervous system support during hormonal transition Primary Active Organic Ashwagandha Root (Withania somnifera) — 1000 mg per serving An adaptogenic herb shown to support stress resilience, mood stability, and sleep regulation. Formulation Rationale Hormonal changes and stress can disrupt mood regulation and sleep patterns. This formulation combines Ashwagandha with black pepper to enhance absorption and maximize physiological impact. Organic Black Pepper (Piper nigrum) — Increases bioavailability of active constituents in Ashwagandha. The formulation is designed for daily use to support multiple pathways involved in stress response, mood regulation, and sleep quality without sedation Key Characteristics Clinically aligned Ashwagandha dosage Black pepper–enhanced absorption Vegan, non-GMO, gluten-free, sugar-free Free from artificial fillers and preservatives Manufactured in a GMP-certified, FDA-registered facility Full Ingredient List Organic Ashwagandha Root Organic Black Pepper Vegetable Capsule *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Trust Center Verified Comprehensive analysis of clinical research and evidence* Mood & Sleep Support By Menopause Science Clinical research shows that up to 80% of perimenopausal women experience mood disturbances and sleep problems. Mood and Sleep Support provides organic ashwagandha root enhanced with black pepper extract for maximum bioavailability and effectiveness.* View Product Research Summary Clinical research suggests that ashwagandha supplementation may significantly reduce perceived stress, anxiety, and improve sleep quality while supporting healthy cortisol levels. Studies specifically in perimenopausal women suggest that ashwagandha may reduce total menopause symptom scores, with particular benefits for psychological symptoms, mood disturbances, and sleep disruption. The addition of black pepper extract (piperine) may enhance absorption, potentially ensuring optimal therapeutic benefits.* Research at a Glance Ingredient Population Studied Studied Benefit(s) Research Link Ashwagandha (600mg daily) 100 perimenopausal women aged 45-60 8-week RCT: Significant reduction in total menopause symptoms, anxiety, irritability, and depressive symptoms vs placebo View Study Ashwagandha (300mg 2x daily) 64 adults with chronic stress 60-day RCT: 44% reduction in stress scores, significant reduction in anxiety and cortisol levels View Study Ashwagandha (240mg daily) 60 stressed adults 60-day RCT: Significant reduction in anxiety (HAM-A scale) and morning cortisol levels vs placebo View Study Ashwagandha 400 participants across 5 studies Meta-analysis: Significant improvement in overall sleep quality, sleep onset latency, and total sleep time View Study Ashwagandha (300mg 2x daily) 60 insomnia patients 10-week RCT: Significant improvement in sleep onset latency, sleep efficiency, and quality vs placebo View Study Black Pepper (Piperine) Various supplement studies Bioavailability enhancer: Increases absorption of herbal compounds by inhibiting liver enzymes View Study Plain Language Summary Ashwagandha has been studied in adults, including women going through perimenopause, for its potential role in reducing stress, supporting mood, and improving sleep. Several clinical trials suggest it may help lower perceived anxiety, support healthier cortisol levels, and improve sleep quality. When combined with black pepper extract, absorption may be enhanced, which could increase effectiveness.* Key Citations Primary Research in Perimenopausal Women: Gopal S, et al. Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study. J Obstet Gynaecol Res. 2021;47(12):4414-4425. PubMed: 34553463 Supporting Stress and Anxiety Research: Chandrasekhar K, et al. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012;34(3):255-262. PubMed: 23439798 Lopresti AL, et al. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract. Medicine. 2019;98(37):e17186. Medicine Journal Sleep Research: Cheah KL, et al. Effect of Ashwagandha (Withania somnifera) extract on sleep: A systematic review and meta-analysis. PLoS One. 2021;16(9):e0257843. PubMed: 34559859 Langade D, et al. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study. Cureus. 2019;11(9):e5797. PMC: 6827862 Bioavailability Enhancement Research: Dudhatra GB, et al. A comprehensive review on pharmacotherapeutics of herbal bioenhancers. ScientificWorldJournal. 2012;2012:637953. PMC: 3634921 Tired of Crying at Commercials and Staring at the Ceiling? Stop sobbing over paper towel ads. Add to cart instead and try Mood & Sleep Support by Menopause Science today. Shop Now Important Disclaimer These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Always consult with your healthcare provider before starting any new supplement regimen, especially if you have pre-existing health conditions or are taking medications. The research cited represents studies conducted on individual ingredients and may not reflect the specific formulation of this product. Individual results may vary based on sleep hygiene, stress levels, health status, and other factors. The research cited represents potential benefits and does not guarantee specific outcomes for all users.
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