Specification Full name ATF6B rabbit polyclonal antibody Alternative names 50 μl/100 μl Reactivity rabbit polyclonal Applications WB, IHC Host Rabbit Clone type rabbit polyclonal Target Background The protein encoded by this gene is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. Swissprot No Q99941 Gene Accession BC008394 WB Predicted band size 77 kDa WB Positive control WB Recommended dilution 500-2000 IHC predicted cell location Predicted cell location: Cytoplasm and Nucleus IHC positive control Positive control: Human colorectal cancer IHC Recommed dilution Recommended dilution: 25-100 Storage -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol WB PIC Description P101275-WB-1-P IHC PIC Description Immunohistochemical analysis of paraffin-embedded Human colorectal cancer tissue or ATF6B antigen-treated (Neutralization experiment) using P101275(ATF6B Antibody) at dilution 1/30
