Specification Full name BCAS2 rabbit polyclonal antibody Alternative names 50 μl/100 μl Reactivity rabbit polyclonal Applications WB, IHC Host Rabbit Clone type rabbit polyclonal Target Background BCAS2 (breast carcinoma amplified sequence 2), also designated DAM1 (DNA amplified in mammary carcinoma 1 protein) or spliceosome-associated SPF 27, is a ubiquitously expressed nuclear protein that was originally identified as being overexpressed in various breast cancer cell lines. BCAS2 is now known to be a component of the spliceosome, participating in the removal of introns from mRNA precursors. BCAS2 specifically interacts (in a ligand-independent manner) with TRβ (thyroid hormone receptor beta), ERα (estrogen receptor alpha), ERβ, PR (progesterone receptor), and PPARγ (Peroxisome proliferator-activated receptor gamma). BCAS2 functions as an ER coactivator and is capable of enhancing ER-mediated transcription. This suggests that BCAS2 is involved in the development of breast cancer. Swissprot No O75934 Gene Accession BC005285 WB Predicted band size 26 kDa WB Positive control WB Recommended dilution 200-1000 IHC predicted cell location Predicted cell location: Nucleus IHC positive control Positive control: Human colon cancer IHC Recommed dilution Recommended dilution: 50-200 Storage -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol WB PIC Description P100665-WB-1-P IHC PIC Description Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue or BCAS2 antigen-treated (Neutralization experiment) using P100665(BCAS2 Antibody) at dilution 1/50
