√ Maintains healthy advanced glycation end (AGE) product activity and glucose metabolism already within the normal range* Supports optimal thiamine pyrophosphate activity with the lipid-soluble, enhanced-retention thiamin derivative benfotiamine* Promotes healthy transketolase activity, an important enzyme in glucose metabolism, to protect vascular tissues through three biochemical pathways* √ Promotes vascular, retinal, kidney and neuronal health* In a randomized cross-over trial, benfotiamine supported healthy flow mediated dilation and endothelial function in response to a heat-treated meal* In another randomized controlled study, benfotiamine supported healthy nerve conduction velocity and nerve comfort* Research suggests that benfotiamine may maintain healthy renal glomeruli and retinal function, as well as moderate protein kinase C enzyme activity, AGE production and protein glycation* Maintains healthy activity of the genomic regulator NF-κB to support cytokine balance*