Berberine is a well-researched botanical that has been tested in numerous clinical studies. It has a long history of use in traditional Ayurvedic and Chinese herbal practices, where it is used for a broad number of applications. Thorne’s high-quality berberine products, Berbercap® and Berberine-500, have a wide range of health and wellness benefits. Benefits of Berberine: Provides immune function support and helps maintain healthy respiratory tract mucus membranes* Promotes healthy blood sugar metabolism and insulin sensitivity* Supports beneficial bacterial balance in the gut and helps to maintain a healthy microbiome* Studies have shown that Berberine can be effective in helping maintain a healthy weight* Supports healthy cholesterol levels* Suggested Use / Directions:Take 1-2 capsules two times daily with food or as recommended by your health-care practitioner.Serving Size:Two CapsulesAmount Per Serving: Berberine HCl (from Indian Barberry extract) (root) (Berberis aristata) ... 450 mgBerberine Phytosome† (Berberis aristata extract (root) / Phospholipid complex from Pea, Sunflower, Grape Seed) ... 550 mg Other Ingredients:Hypromellose (derived from cellulose) capsule, calcium laurate. ALLERGY WARNINGThis product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.PREGNANCY WARNINGIf pregnant, nursing, or trying to conceive, do not use this product.INTERACTIONSHas been shown to decrease the activity of the cytochrome p450 (CYP) enzymes CYP2D6, CYP2C9, and CYP3A4. Individuals with a known, serious allergy to peanuts may occasionally react to other legumes, including peas. This product contains pea protein. If you have a known, serious peanut allergy, it is recommended to use this product with caution.