Bipolar Disorders

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Allan Young Edited by Jair C. SoaresCambridge University PressEdition: 3, 4/30/2016EAN 9781107062719, ISBN10: 1107062713Hardcover, 288 pages, 25.4 x 19.4 x 1.8 cmLanguage: EnglishO ver the past two decades, driven by the enormous public health importance of bipolar disorder, research initiatives have begun to elucidate the pathophysiology of this prevalent and debilitating condition. These research initiatives have led to breakthroughs in our understanding of causation, and now promise to foster the development of novel treatments. This new edition presents contributions from the leaders at the forefront of these areas of research, and includes chapters on the groundbreaking advances in the fields of genetics, neuroimaging, neuropsychopharmacology, oxidative stress and neuronal resilience, inflammatory mechanisms, psychosocial factors, childhood onset and late-life bipolar disorder, and many other important areas. Throughout, the therapeutic implications and potential of this new understanding are emphasized. This will be essential reading for those interested in the neurobiology of mental illness, and will be of interest to mental health practitioners more generally.List of contributorsPreface1. The classification of bipolar disordersimplications for clinical research Michael J. Ostacher, Mark A. Frye and Trisha Suppes2. Prospects for the development of animal models for the study of bipolar disorder Trevor R. Norman3. Abnormalities in catecholamines and the pathophysiology of bipolar disorder Alexander W. Charney, Sehrish Sayed and Dennis S. Charney4. Serotonergic dysfunction in bipolar disorder Martin J. Lan and J. John Mann5. Involvement of GABAergic/glutamatergic pathways in mood disorders Paul Stokes and James Stone6. Oxidative stress and neuronal resilienceimplications for the pathophysiology of bipolar disorders Gabriela Delevati Colpo, Gabriel Rodrigo Fries, Laura Stertz and Flávio Kapczinski7. Post-mortem studies in bipolar disorder Francine M. Benes and Sivan Subburaju8. The neuroendocrinology of stress in the pathophysiology of bipolar disorders Allan H. Young and Alessandro Colasanti9. Brain imaging abnormalities in bipolar disorder Marsal Sanches and Jair C. Soares10. Sleep and circadian rhythms in bipolar disorders Sara Dallaspezia and Francesco Benedetti11. Infectious agentsrole in causation of bipolar disorders? Olaoluwa O. Okusaga12. EEGs and ERPs in bipolar disorders R. Hamish McAllister-Williams13. Genetic factors in the etiology of bipolar disorder Consuelo Walss-Bass14. Neurocognitive findings in bipolar disorder David C. Glahn, Carrie E. Bearden and Sophia Frangou15. Psychotherapeutic interventions in bipolar disorder Thomas Daniel Meyer16. The kindling/sensitization model and the pathophysiology of bipolar disorder Robert M. Post17. Biological factors in bipolar disorder in childhood and adolescence Melissa A. Brotman, Banafsheh Sharif-Askary, Daniel P. Dickstein and Ellen Leibenluft18. Biological factors in bipolar disorder in late life Brent Forester, Ariel G. Gildengers and Robert C. Young19. Perspectives for new pharmacological interventions Charles L. Bowden20. Physical health and metabolic dysfunction in bipolar disorder Joshua D. Rosenblat, Danielle S. Cha, Rodrigo B. Mansur and Roger S. McIntyre21. Immune dysregulation in bipolar disorder Antonio Lucio Teixeira, Izabela Guimarães Barbosa and Moisés Evandro BauerIndex. Show more