Cambridge University PressEdition: Illustrated, 2/15/2007EAN 9780521834919, ISBN10: 0521834910Hardcover, 662 pages, 24.4 x 17 x 3.7 cmLanguage: EnglishNorepinephrine is a chemical neurotransmitter. Drugs that directly manipulate central nervous system (CNS) norepinephrine are being developed targeting noradrenergic neurons to deliver therapeutic effects. Noradrenergic drugs have been proven effective for depression and ADHD, and new disease indications are being identified. A team of experts provides the reader with a thorough understanding of the anatomy, physiology, molecular biology, pharmacology and therapeutics of norepinephrine in the brain, including an extensive review of the role of norepinephrine in brain diseases. The book is divided into four sections: the basic biology of norepinephrine; the role that norepinephrine plays in behavior; evidence of norepinephrine's role in CNS diseases, and the pharmacology and therapeutics of noradrenergic drugs in the treatment of psychiatric and neurological disorders.Introductionrevision of an old transmitter Gregory A. OrdwayPart I. The Neurobiology of Norepinephrine1. Neuroanatomical and chemical organization of the locus coeruleus Kimberly L. Simpson and Rick C. S. Lin2. Interactions of norepinephrine with other neurotransmitter systemsanatomical basis and pharmacology Craig A. Stockmeier and Gregory A. Ordway3. Receptors for norepinephrine and signal transduction pathways David B. Bylund4. Regulation of gene transcription in the central nervous system by norepinephrine Ronald S. Duman and Samuel S. Newton5. The norepinephrine transporter and regulation of synaptic transmission Subbu ApparsundaramPart II. Norepinephrine and Behavior6. Role of the locus coeruleus-norepinephrine system in arousal and circadian regulation of the sleep wake cycle Gary S. Aston-Jones, Monica Gonzalez and Scott Doran7. Locus coeruleus and regulation of behavioral flexibility and attentionclinical implications Gary S. Aston-Jones, Michiyo Iba, Edwin Clayton, Janusz Rajkowski and Jonathan Cohen8. Norepinephrine and long-term memory function Benno Roozendaal9. Norepinephrine and stress David A. MorilakPart III. The Biology of Norepinephrine in CNS Pathology10. Animal models of psychopathologyfocus on norepinephrine Leonie A. M. Welberg and Paul Plotsky11. Neuropathology of central norepinephrine in psychiatric disorderspostmortem research Gregory A. Ordway12. Norepinephrine in mood disorders Pedro L. Delgado and Cristinel Coconcea13. Noradrenergic pathology and pain Antti Pertovaara14. Norepinephrine in cognitive disorders Amy F. T. Arnsten15. Norepinephrine in neurological disorders Francesco Fornai16. Genetics of noradrenergic neurobiology Inna Belfer and David GoldmanPart IV. Psychopharmacology of Norepinephrine17. Actions of antidepressant and other drugs on norepinephrine systems Elliott Richelson18. The clinical role of norepinephrine antidepressants in depression and anxiety disorders J. Craig Nelson19. Norepinephrine in attention deficit hyperactivity disorder Fred W. Riemherr, Michael A. Schwartz, B. K. Marchant and E. Higgins20. Psychopharmacology of norepinephrine in eating disorders Katherine A. Halmi and Sun Young Yum21. Role of norepinephrine in substance abuse Susan L. Broom and Bryan K. Yamamoto.
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