Overview Cyanidin 3-glucoside (C3G) is a potent antioxidant belonging to a class of flavonoids known as anthocyanins. Like other anthocyanins, cyanidin-3-glucoside is an organic pigment that gives various fruits, vegetables, and plants distinctive red, purple, and blue tones. Transparent Labs C3G supplement contains 300 mg of purified cyanidin 3-glucoside per serving, whereas common food sources of C3G, notably berries, may only provide a few milligrams per 100-gram serving. As such, achieving therapeutic doses of cyanidin 3-glucoside via food alone can be challenging, if not impractical. Our C3G supplement makes it easier to reap the metabolic, cognitive, neurological, anti-inflammatory, and body composition benefits of this versatile anthocyanin. Key Features Purified and Highly Concentrated Cyanidin 3-Glucoside (C3G) Supplement: Transparent Labs C3G capsules are a single-active-ingredient formula that provides 300 mg C3G per serving, equal to the amount of C3G in nearly one pound of fresh blackberries (one of the most dense food sources of C3G). With 90 capsules (30 servings) per bottle, this C3G supplement is priced to be an exceptional, high-quality addition to your healthy lifestyle. Versatile Antioxidant and Anti-Inflammatory Nutrient: Like other anthocyanins, cyanidin 3-glucoside has a strong antioxidant capacity, neutralizing free radicals (e.g. reactive oxygen species) that can harm cellular integrity and function. It also possesses anti-inflammatory properties by modulating pro-inflammatory cytokines, such as tumor necrosis factor-alpha. Enhances Insulin Sensitivity/Glucose Uptake and Fat-Burning Gene Expression: Cyanidin 3-glucoside is gaining traction as a potential adjunct in the treatment of various metabolic disorders (e.g. type-2 diabetes and metabolic syndrome) due to its positive impact on insulin sensitivity and thermogenesis (i.e. calorie-burning). Thus, taking a C3G supplement may help combat fat gain and support healthy body composition. Third-Party Tested for Purity, Potency, and Authenticity: Our commitment to full product transparency and quality assurance means each batch of Transparent Labs C3G capsules undergoes third-party testing to ensure each serving meets or exceeds the label claim of 300 mg cyanidin 3-glucoside. Active Ingredients and Benefits Cyanidin 3-Glucoside | 300 mg Cyanidin 3-glucoside (C3G) is a naturally occurring anthocyanin, which is a type of flavonoid pigment responsible for the red, purple, and blue hues in various fruits and vegetables. Chemically, C3G is classified as a glycoside, consisting of the anthocyanidin cyanidin coupled with a glucose (sugar) moiety. Its molecular structure engenders high solubility in water, allowing for efficient absorption in the upper digestive tract. Additionally, C3G has high bioavailability and can readily traverse cell membranes and biological barriers, including the blood-brain barrier, which underpins its versatile therapeutic potential throughout the body.Among the most notable benefits of C3G is its antioxidant properties. By neutralizing free radicals, C3G can reduce oxidative stress and mitigate damage to cellular structures and biologically important molecules [2]. Uncontrolled oxidative stress is a well-known culprit for numerous disease states, including cardiovascular disease, type-2 diabetes, and cancer [3].Aside from its antioxidant role, cyanidin 3-glucoside appears to have extensive and tissue-specific mechanisms of action. While we won't go into specific details herein, for the sake of brevity, it's important to note that C3G has been shown to modulate several key biochemical pathways and physiological processes that regulate weight/composition, insulin sensitivity/blood glucose levels, nitric oxide production, inflammatory response, neurological function, visual acuity, and more [4, 5, 6, 7, 8, 9]. How to Use Take 3 capsules daily, preferably before a meal earlier in the day. Do not exceed 3 capsules (300 mg of cyanidin 3-glucoside) per day unless otherwise directed by a qualified healthcare practitioner. Optimal Consumption Times While cyanidin 3-glucoside can be taken at any time, we recommend taking it with breakfast and again early in the afternoon to take advantage of its thermogenic benefits throughout the day. FAQs What Are the Benefits of Taking C3G Supplements? Cyanidin 3-glucoside (C3G) confers antioxidant and anti-inflammatory benefits, which may reduce the risk of chronic diseases, improve heart health, and aid in weight management. It also holds potential as a neuroprotective, anti-cancer, anti-diabetic, and anti-thrombotic agent. For example, tumor necrosis factor-alpha (α) is a pro-inflammatory cytokine involved in systemic inflammation and is implicated in various pathological conditions, including the progression of cancer cells and metabolic disorders. C3G has been shown to downregulate tumor necrosis factor-α expression, significantly mitigating inflammatory responses [10]. The comprehensive benefits make C3G a valuable supplement for overall health and longevity. How Does C3G Work? C3G is absorbed into the bloodstream in its parent form, bolstering antioxidant capacity and reducing oxidative stress. It stimulates hepatic (liver) fatty acid oxidation, ketogenesis, and lipolysis in white adipose tissue while promoting mitochondrial oxidative metabolism and thermogenesis in brown adipose tissue. These mechanisms enhance cardiovascular, metabolic, and cognitive health. Are There Any Side Effects of C3G Supplementation? Cyanidin 3-glucoside is generally considered safe at recommended dosages, with no significant adverse effects reported. However, individual evaluation is advised, especially for those with underlying conditions or on medications. Consulting a healthcare professional before using a cyanidin 3-glucoside supplement is prudent. Can C3G Improve Cognitive Function and Brain Health? Evidence suggests cyanidin 3-glucoside has neuroprotective properties that support cognitive function and brain health by mitigating neuronal damage and reducing neurodegenerative disease risk. Thus, it may improve memory, learning, and overall cognitive function. How Does C3G Support Metabolic Health? Cyanidin 3-glucoside supports metabolic health by enhancing mitochondrial oxidative metabolism and thermogenesis in brown adipose tissue, reducing body fat accumulation, and stimulating hepatic fatty acid oxidation, ketogenesis, and lipolysis in white adipose tissue. Studies in rodents have shown that both mice and isolated rat adipocytes treated with cyanidin 3-glucoside had significant changes in adipocyte-specific gene expression, suggesting particular anthocyanin enhances adipocytokine secretion [11, 12]. Cyanidin 3-glucoside also lowers blood glucose levels and improves insulin sensitivity by activating adenosine monophosphate-activated protein kinase (AMPk). These effects make it promising for preventing and managing metabolic syndrome. Can C3G Aid in Muscle Recovery and Performance? Cyanidin 3-glucoside aids muscle recovery and performance by reducing oxidative stress and inflammation following intense exercise. This promotes faster recovery, allowing for consistent training and enhanced endurance.
