What is CDG (Calcium D-Glucarate)? Calcium D-Glucarate, also known as calcium saccharate and saccharated lime, is a calcium salt combined with glucaric acid. The addition of glucaric acid dramatically improves the calcium’s oral bioavailability. Once ingested, stomach acids break down calcium D-glucarate into calcium and D-glucaric acid. Calcium is an essential mineral and electrolyte that the body needs to maintain the circulatory, digestive, and muscular systems. It is also critical for bone formation, blood cell function, muscle contractions, and nerve conduction. Glucaric acid occurs naturally in many fruits and vegetables, including apples, grapefruits, oranges, and cruciferous vegetables like broccoli. D-glucarate has antioxidant and anti-inflammatory properties that help rid the body of toxins and support the body’s natural defense systems. Glucaric acid also helps remove excess estrogen. Additionally, calcium D-glucarate exerts beneficial effects on cholesterol levels. Potential Calcium D-Glucarate Benefits Calcium D-Glucarate + Liver Health Calcium D-glucarate may support liver health due to its detoxification properties. The liver goes through two phases of detoxing harmful substances. The first phase can sometimes produce metabolites that are more noxious than the original compounds. The second phase targets these metabolites for elimination in a process known as glucuronidation. Phase II detoxification also processes harmful metabolic byproducts, hormones, and medications. Glucuronidation neutralizes these toxins by binding them to glucuronic acid. The body can then excrete them through the gut or kidneys via bile, bowel movements, and urine. However, beta-glucuronidase enzymes found in the gut can reverse glucuronidation and cause the body to reabsorb the toxins the liver tried to eliminate. Calcium D-glucarate inhibits beta-glucuronidase activity, which may help attenuate a buildup of toxins in the body. Calcium D-Glucarate and Resveratrol Antioxidants Calcium D-glucarate shows significant synergy with resveratrol by boosting its antioxidant properties. Calcium D-Glucarate + Estrogen The body needs beta-glucuronidase to metabolize carbohydrates and produces the enzymes via colon bacteria. However, high-fat diets, processed foods, excess sugar consumption, and insufficient fiber intake can cause an imbalance of beta-glucuronidase in the gut. As mentioned above, beta-glucuronidase can unbind excess hormones packaged via glucuronidation before the body can eliminate them. Numerous scientific studies support the connection between the gut and sex hormones. Calcium D-glucarate can help restore gut health by blocking beta-glucuronidase enzymes and preserving glucuronidation. Excess estrogen can lead to numerous health problems in men and women alike. An imbalance of estrogen and testosterone in women can cause breast tenderness, low sex drive, mood swings, irregular periods, worse PMS symptoms, weight gain, weight loss resistance, hair loss, headaches, endometriosis, polycystic ovarian syndrome (PCOS), and thyroid disorders. Long-term estrogen elevation also has strong ties to breast, ovarian, and uterine cancers, as these malignancies rely on estrogen to grow and proliferate. Men with too much estrogen may experience fertility problems due to low sperm count, erectile dysfunction, breast growth, and reduced libido. Men with high estrogen may also have a higher risk of developing breast cancer. Calcium D-Glucarate + Cholesterol D-glucarate supplements show significant potential for balancing cholesterol levels. Animal trials reported a 12-15% decrease in total cholesterol and a 30-35% decrease in LDL (bad) cholesterol. Preliminary research shows D-glucarate has similar effects on humans and reduces total cholesterol by up to 12%, LDL cholesterol by up to 28%, and triglycerides (another type of fat found in the blood) by up to 43%. Researchers believe that calcium D-glucarate exerts these effects by reducing beta-glucuronidase production, which provides better liver circulation. Enhancing liver circulation helps lower cholesterol levels by increasing bile acid secretion and reducing cholesterol synthesis. Calcium D-Glucarate + Weight Loss Calcium D-glucarate may support weight loss efforts due to its interactions with hormones. Excess estrogen can cause weight gain and make it difficult to lose weight. Balancing the estrogen gut microbiome may alleviate these problems. Calcium D-Glucarate + Bones The body needs ample calcium to develop and maintain strong bones and teeth, and eating a calcium-rich diet can promote long-term bone health. Calcium intake is particularly important for the elderly to prevent bone loss, maintain bone strength, and sustain bone mineral density. Elderly individuals are less likely to experience bone fractures when taking calcium supplements with . Vitamin D helps the body absorb calcium, and vitamin D deficiencies tend to presage calcium deficiencies. Potential Calcium D-Glucarate Side Effects Current studies report no significant side effects from taking calcium D-glucarate. However, calcium D-glucarate may interact with other medications broken down by the liver. Taking calcium D-glucarate with alcohol may reduce its effectiveness. Calcium D-glucarate may reduce the effectiveness of the antibiotic kanamycin. Resources and References https://pubmed.ncbi.nlm.nih.gov/12197785 https://www.cancer.gov/publications/dictionaries/cancer-drug/def/calcium-saccharate https://lpi.oregonstate.edu/mic/minerals/calcium https://ods.od.nih.gov/factsheets/Calcium-HealthProfessional https://pubchem.ncbi.nlm.nih.gov/compound/Calcium-saccharate https://pubchem.ncbi.nlm.nih.gov/compound/Calcium-glucarate https://www.ncbi.nlm.nih.gov/pubmed/3779687 https://www.ncbi.nlm.nih.gov/pubmed/2346674 https://www.ncbi.nlm.nih.gov/pubmed/2967969 https://www.ncbi.nlm.nih.gov/pubmed/3115856 https://pubmed.ncbi.nlm.nih.gov/18772850 https://www.frontiersin.org/articles/10.3389/fmicb.2021.711137/full https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971312 https://www.ncbi.nlm.nih.gov/books/NBK538260 https://www.cancer.gov/about-cancer/causes-prevention/risk/hormones https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854098 https://pubmed.ncbi.nlm.nih.gov/28778332 https://www.sciencedaily.com/releases/2015/05/150511172700.htm https://www.sciencedirect.com/science/article/abs/pii/0271531796000450 https://altmedrev.com/wp-content/uploads/2019/02/v7-4-336.pdf https://pubmed.ncbi.nlm.nih.gov/18412990 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4784799 https://pubmed.ncbi.nlm.nih.gov/12916289 https://www.ncbi.nlm.nih.gov/books/NBK532266 https://pubmed.ncbi.nlm.nih.gov/17846905
