NeuroScience Calm CP Decrease cortisol to maintain healthy activity while providing ingredients important for optimal sleep, calm, and management of healthy blood sugar Patient Profile: Experiencing stress (acute, sustained or immune) Consistently interrupted sleep Difficulty falling back asleep New or increasing abdominal fat The Science: In response to stress, the sympathetic nervous system (SNS) and hypothalamic-pituitary-adrenal (HPA) axis signal to the adrenals to release catecholamines (norepinephrine and epinephrine) and cortisol While stress is a normal part of life, it can also be associated with imbalances in the HPA axis that can affect catecholamine and cortisol activity Ingredients Serving Size: 2 Capsules Amount/Serving Proprietary Blend: 667 mg Phosphatidylserine 50%, L-glycine, L-taurine, and Banaba extract (Lagerstroemia speciosa) (leaf) (18% corosolic acid) Other Ingredients: Organic rice concentrate, vegetable capsule (hypromellose, water), and silica. Suggested Use Take 2 capsules one to two times daily or as directed by your healthcare provider. Do not exceed the suggested use. Warning: If you are pregnant or nursing, consult your healthcare provider before use. Keep out of reach of children. Storage: This product has a tamper-evident seal under the cap. Do not use if the seal is broken or missing. Store at room temperature, in a dry place. More Info. Stress, cortisol, and weight Cortisol secretion follows a marked circadian pattern and increases in response to stress through activation of the HPA axis Adipocytes (fat cells) play a major role in the body’s production of cortisol High stress has been linked to less healthy dietary behaviors and increased body weight Cortisol inhibits the secretion and actions of insulin (glucose uptake, central appetite reduction) Cortisol promotes the maturation of adipocytes (fat cells) Upregulation of the enzyme 11β-HSD1 promotes fat accumulation by increasing cortisol levels Elevated bedtime cortisol levels are associated with increased abdominal fat Proven benefits of Calm CP A randomized study with corosolic acid was shown to significantly lower blood glucose levels 10 subjects were prescreened and selected to receive corosolic acid once daily for 15 days Blood glucose levels were 20-30% lower after two weeks The effectiveness of Calm CP was analyzed in a study Participants were prescreened for elevated cortisol levels Calm CP (2 capsules twice daily for 4 days) significantly lowered total daily cortisol levels (area under the curve - AUC) compared to baseline values Calm CP decreased mean daily cortisol levels by 17% 71% of participants reported they would take Calm CP again
